Plasmodium falciparum malaria and human red cells. II. Red cell genetic traits and resistance against malaria

International Journal of Epidemiology
I Guggenmoos-HolzmannL Luzzatto

Abstract

In 702 Nigerian children under 6 years of age the incidence and the severity of malarial infection was studied with respect to haemoglobin types and red cell glucose-6-phosphate dehydrogenase variants. The results suggest that Hb AS as well as the female genotype GdA-/GdB offer selective advantage against the disease. Parasite densities in carriers of these genotypes were significantly lower than in other subjects. Whereas protection by Hb AS was found mainly in children between 2 and 4 years of age, the advantage afforded by GdA-/GdB was similar in all age groups. Possible mechanisms are discussed.

Citations

Sep 1, 1992·Transactions of the Royal Society of Tropical Medicine and Hygiene·S J AllenB M Greenwood
Oct 15, 2011·The Journal of Infectious Diseases·Thomas N Williams
May 27, 2005·PLoS Medicine·Thomas N WilliamsKevin Marsh
Nov 22, 2012·Mediterranean Journal of Hematology and Infectious Diseases·Lucio Luzzatto
Feb 14, 2004·Redox Report : Communications in Free Radical Research·David J Roberts, Thomas N Williams
Mar 27, 2012·The Lancet Infectious Diseases·Steve M TaylorRick M Fairhurst
Jan 8, 2008·Lancet·M D Cappellini, G Fiorelli
Jun 18, 2005·Tropical Medicine & International Health : TM & IH·Jakob P CramerFrank P Mockenhaupt
May 14, 2005·Journal of Applied Physiology·Robin E Pattillo, L Bruce Gladden
Jun 17, 2004·Blood·Frank P MockenhauptUlrich Bienzle
Jan 1, 1990·American Journal of Human Biology : the Official Journal of the Human Biology Council·Fatimah Linda Collier Jackson

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