Plasmodium falciparum malarial parasites from Brazil lack artemisinin resistance-associated mutations in the kelch13 gene.

Revista Da Sociedade Brasileira De Medicina Tropical
Francesca ChapadensePedro Cravo

Abstract

Mutations in the propeller domain of the Plasmodium falciparum kelch13 (k13) gene are associated with artemisinin resistance. We developed a PCR protocol to sequence the pfk13 gene and determined its sequence in a batch of 50 samples collected from 2003 to 2016 in Brazil. We identified 1 K189T substitution located outside the propeller domain of the PfK13 protein in 36% of samples. Although the sample size is relatively small, these results suggest that P. falciparum artemisinin-resistant mutants do not exist in Brazil, thereby supporting the continuation of current treatment programs based on artemisinin-based combination therapy.

References

Apr 25, 2007·Nucleic Acids Research·Warren A Kibbe
Dec 20, 2013·Nature·Frédéric ArieyDidier Ménard
May 23, 2014·The Lancet Infectious Diseases·Chanaki AmaratungaRick M Fairhurst
Jan 20, 2015·Nature Genetics·Olivo MiottoDominic P Kwiatkowski
Nov 5, 2015·Expert Review of Anti-infective Therapy·Toshihiro MitaMakoto Hirai
Dec 23, 2015·The Journal of Infectious Diseases·Stella M ChenetVenkatachalam Udhayakumar
Apr 14, 2016·The American Journal of Tropical Medicine and Hygiene·Simone Ladeia-AndradeMarcelo U Ferreira

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Citations

Aug 12, 2021·The Journal of Antimicrobial Chemotherapy·Luana C MathieuLise Musset

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