Plasmodium falciparum parasites expressing pregnancy-specific variant surface antigens adhere strongly to the choriocarcinoma cell line BeWo.

Infection and Immunity
Rikke N HaaseTrine Staalsoe

Abstract

Placenta-sequestering Plasmodium falciparum parasites causing pregnancy-associated malaria express pregnancy-specific variant surface antigens (VSA(PAM)). We report here that VSA(PAM)-expressing patient isolates adhere strongly to the choriocarcinoma cell line BeWo and that the BeWo line can be used to efficiently select for VSA(PAM) expression in vitro.

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Citations

Jan 26, 2007·The Lancet Infectious Diseases·Stephen J RogersonDiane W Taylor
Jul 13, 2011·Proceedings of the National Academy of Sciences of the United States of America·Lea BarfodLars Hviid
Mar 15, 2011·The Journal of Biological Chemistry·Madeleine DahlbäckAli Salanti
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May 12, 2017·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Casper Hempel
Nov 17, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Lea BarfodLars Hviid
May 11, 2017·Malaria Journal·Casper HempelTrine Staalsø

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