Plasmodium falciparum transmission blocking immunity under conditions of low and high endemicity in Cameroon

Parasite Immunology
C BoudinJ P Verhave

Abstract

Transmission blocking immunity (TBI) was studied in relation to age, gametocyte density and transmission intensity. subjects with high gametocytaemias were selected in a hypo-endemic urban district and a hyper-endemic rural area in South Cameroon. TBI was determined in blood from gametocyte carriers in a bioassay (Direct Membrane Feeding Assay), with either autologous plasma (OWN) or control serum (AB). Mosquito infection rates (IR) were compared. infection rates correlated positively with gametocyte and oocyst densities. Three TBI indicators were analysed: the proportion of transmission reducers (IRAB > IROWN, P < 0.01), the mean intensity of TBI (IRAB - IROWN), and the contribution of TBI to total inhibition [(IRAB-IROWN)/(100-IROWN)]. we could not discriminate between areas with regard to either the proportion of transmission reducers (urban 15% and rural 29%) or the mean levels of TBI (urban 10% and rural 9%), or contribution of TBI to total inhibition (urban 10% and rural 13%). there was no relationship between TBI indicators and age, but a trend of increasing values was observed with rising gametocytaemia, which was considered as a confusing factor. a multivariable analysis showed that the probability of being a reducer w...Continue Reading

References

Feb 1, 1991·The American Journal of Tropical Medicine and Hygiene·J K BairdB Leksana
Jan 1, 1987·Transactions of the Royal Society of Tropical Medicine and Hygiene·T PonnuduraiJ H Meuwissen
May 1, 1986·Parasite Immunology·Y D MunesingheR Carter
Nov 13, 1984·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·R CarterD Wirth
Jan 1, 1996·Transactions of the Royal Society of Tropical Medicine and Hygiene·A LensenR Sauerwein
Nov 24, 1999·Infection and Immunity·K P PiperK P Day
Mar 21, 2002·Tropical Medicine & International Health : TM & IH·S BonnetC Boudin
Apr 1, 1997·Parasitology Today·L H Taylor, A F Read

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Citations

Sep 13, 2013·BMC Infectious Diseases·Lindsay T Keegan, Jonathan Dushoff
Sep 14, 2007·Malaria Journal·Richard E PaulVincent Robert
Jun 23, 2006·International Journal for Parasitology·Mike van der KolkRobert W Sauerwein
Oct 27, 2010·International Journal for Parasitology·Teun BousemaChris J Drakeley
Sep 9, 2011·Memórias do Instituto Oswaldo Cruz·Myriam Arévalo-HerreraSócrates Herrera Valencia
Aug 26, 2006·The American Journal of Tropical Medicine and Hygiene·Gerry F KilleenThomas Smith

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