Plasmodium falciparum variant surface antigen expression varies between isolates causing severe and nonsevere malaria and is modified by acquired immunity

The Journal of Immunology : Official Journal of the American Association of Immunologists
Morten A NielsenL Hviid

Abstract

In areas of endemic parasite transmission, protective immunity to Plasmodium falciparum malaria is acquired over several years with numerous disease episodes. Acquisition of Abs to parasite-encoded variant surface Ags (VSA) on the infected erythrocyte membrane is important in the development of immunity, as disease-causing parasites appear to be those not controlled by preexisting VSA-specific Abs. In this work we report that VSA expressed by parasites from young Ghanaian children with P. falciparum malaria were commonly and strongly recognized by plasma Abs from healthy children in the same area, whereas recognition of VSA expressed by parasites from older children was weaker and less frequent. Independent of this, parasites isolated from children with severe malaria (cerebral malaria and severe anemia) were better recognized by VSA-specific plasma Abs than parasites obtained from children with nonsevere disease. This was not due to a higher infection multiplicity in younger patients or in patients with severe disease. Our data suggest that acquisition of VSA-specific Ab responses gradually restricts the VSA repertoire that is compatible with parasite survival in the semi-immune host. This appears to limit the risk of severe d...Continue Reading

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Citations

Aug 1, 2008·Transboundary and Emerging Diseases·A P Arez, V E do Rosário
Aug 14, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Gerald K K ChamThor G Theander
Dec 19, 2009·Proceedings of the National Academy of Sciences of the United States of America·George M WarimwePeter C Bull
Jan 26, 2016·Scientific Reports·Abdirahman I AbdiPeter C Bull
Jun 30, 2016·EMBO Molecular Medicine·Jakob S JespersenThomas Lavstsen
Jan 11, 2019·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Benjamin MordmüllerMorten A Nielsen
Feb 18, 2020·Virulence·Harsita PatelAubrey J Cunnington
Nov 11, 2003·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·T N Williams, C I Newbold
Feb 22, 2012·Expert Review of Anti-infective Therapy·Raquel GonzálezAlfredo Mayor
Dec 5, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Anja BengtssonAnja T R Jensen
Aug 21, 2013·Cellular Microbiology·Joseph D SmithThomas Lavstsen
Sep 1, 2015·The Journal of Immunology : Official Journal of the American Association of Immunologists·Frank LennartzAnja T R Jensen
Oct 27, 2017·Scientific Reports·Almahamoudou MahamarMichal Fried
Apr 25, 2018·Malaria Journal·Daibin ZhongGuiyun Yan

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