Plasmodium infection and endotoxic shock induce the expansion of regulatory dendritic cells

The Journal of Immunology : Official Journal of the American Association of Immunologists
Kurt A Wong, Ana Rodriguez

Abstract

During an acute Plasmodium infection, uncontrolled proinflammatory responses can cause morbidity and mortality. Regulation of this response is required to prevent immunopathology. We therefore decided to investigate a recently characterized subset of regulatory dendritic cells (DCs) that expresses low levels of CD11c and high levels of CD45RB. During a Plasmodium yoelii infection, these regulatory CD11clowCD45RBhigh DCs become the prevalent CD11c-expressing cells in the spleen, overtaking the conventional CD11chigh DCs. Furthermore, the regulatory CD11clowCD45RBhigh DCs induce IL-10-expressing CD4 T cells. A similar change in splenic DC subsets is seen when mice are injected with sublethal doses of LPS, suggesting that shifting the splenic DC subsets in favor of regulatory CD11clowCD45RBhigh DCs can be triggered solely by a high inflammatory stimulus. This is the first time regulatory DCs have been observed in a natural immune response to an infectious disease or endotoxic shock.

References

Jan 1, 1992·Parasitology·K Marsh
Jan 1, 1966·Transactions of the Royal Society of Tropical Medicine and Hygiene·I Landau, R Killick-Kendrick
Apr 1, 1993·The Journal of Experimental Medicine·M HowardS Menon
May 1, 1997·Infection and Immunity·J B De SouzaJ H Playfair
Dec 22, 1999·The Journal of Immunology : Official Journal of the American Association of Immunologists·F Lepault, M C Gagnerault
Jun 3, 2000·Annual Review of Immunology·J BanchereauK Palucka
Jul 19, 2000·Current Opinion in Immunology·M Plebanski, A V Hill
Jun 8, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·M WysockaC L Karp
Oct 10, 2001·European Journal of Immunology·E SeixasJ Langhorne
Mar 27, 2002·Nature Reviews. Immunology·Ken Shortman, Yong-Jun Liu
May 16, 2002·Infection and Immunity·James LuyendykAnne C Avery
Jan 23, 2003·The Journal of Experimental Medicine·Carlos Ocaña-MorgnerAna Rodriguez
Dec 23, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·James A PerryAnne C Avery
Mar 23, 2004·Annual Review of Immunology·Sergio A QuezadaRandolph J Noelle
Mar 25, 2004·Nature Reviews. Immunology·Mary M Stevenson, Eleanor M Riley
Jun 24, 2004·Infection and Immunity·Andrew L LeisewitzDominic P Kwiatkowski
Nov 4, 2004·Trends in Parasitology·Claire L MackintoshKevin Marsh
Dec 14, 2004·Immunity·Mattias SvenssonPaul M Kaye
May 10, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·James A PerryAnne C Avery
Sep 9, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Dodie S PouniotisMagdalena Plebanski
Nov 23, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mario DelgadoDoina Ganea
Dec 21, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Rebecca IngMary M Stevenson
Mar 22, 2006·The Journal of Experimental Medicine·Megan MacLeodDavid Gray
Jun 7, 2006·The Journal of Experimental Medicine·Anne-Marit SponaasJean Langhorne
Jun 21, 2006·Trends in Parasitology·Craig S BoutlisNicholas M Anstey
Aug 15, 2006·Immunological Reviews·Maria Grazia RoncaroloMegan K Levings
Aug 15, 2006·Immunological Reviews·David M Sansom, Lucy S K Walker
Oct 17, 2006·Nature Reviews. Microbiology·Miguel PrudêncioMaria M Mota
Jan 16, 2007·Cellular Microbiology·Michelle WykesMichael F Good
Feb 28, 2007·Cellular Microbiology·Daniel CarapauAna Rodriguez
May 3, 2007·European Journal of Immunology·Carlos Ocaña-MorgnerAna Rodriguez
May 4, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Saskia deWalickChristian R Engwerda
Jul 10, 2007·PLoS Pathogens·Michelle N WykesMichael F Good
Aug 22, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Irina FernandezEdgar Engleman
Sep 6, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Michelle N WykesMichael F Good

❮ Previous
Next ❯

Citations

Aug 20, 2008·Nature Reviews. Microbiology·Michelle N Wykes, Michael F Good
Sep 26, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mana MiyakodaKatsuyuki Yui
Apr 26, 2016·Journal of Immunology Research·Kelly N S AmorimSilvia B Boscardin
Dec 7, 2017·Scientific Reports·Corentin LasseauxLionel Franz Poulin
Jun 12, 2008·Journal of Cellular and Molecular Medicine·K L Griffiths, H C O'Neill
Dec 17, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Eva PastilleStefanie B Flohé
Mar 6, 2010·Journal of Biomedicine & Biotechnology·César A TerrazasLorena Gómez-García
Oct 30, 2014·Frontiers in Immunology·Christian R EngwerdaPatrick T Bunn
Jun 24, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yanshi WangZhigang Tian
Mar 24, 2009·Annual Review of Immunology·Yasmine Belkaid, Kristin Tarbell
Sep 20, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Alexey PopovJoachim L Schultze
Sep 24, 2008·Journal of Clinical Immunology·Elizabeth Wohlfert, Yasmine Belkaid
May 18, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Katherine A SmithRick M Maizels
May 29, 2008·Future Microbiology·Stephen M Todryk, Britta C Urban
Feb 22, 2012·Immunotherapy·Mohammad W KhanMansour Mohamadzadeh
Dec 4, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Marcela Montes de OcaChristian R Engwerda
Mar 3, 2010·Malaria Journal·Esther BettiolAna Rodriguez

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antimalarial Agents (ASM)

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

Babesiosis

Babesiosis is caused by parasites of the genus babesia, which are transmitted in nature by the bite of an infected tick. Discover the latest research on babesiosis here.

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here

Antimalarial Agents

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.