Plasmodium Parasites Viewed through Proteomics

Trends in Parasitology
Kristian E Swearingen, Scott E Lindner

Abstract

Early sequencing efforts that produced the genomes of several species of malaria parasites (Plasmodium genus) propelled transcriptomic and proteomic efforts. In this review, we focus upon some of the exciting proteomic advances from studies of Plasmodium parasites over approximately the past decade. With improvements to both instrumentation and data-processing capabilities, long-standing questions about the forms and functions of these important pathogens are rapidly being answered. In particular, global and subcellular proteomics, quantitative proteomics, and the detection of post-translational modifications have all revealed important features of the parasite's regulatory mechanisms. Finally, we provide our perspectives on future applications of proteomics to Plasmodium research, as well as suggestions for further improvement through standardization of data deposition, analysis, and accessibility.

Citations

May 7, 2019·Briefings in Functional Genomics·José L Ruiz, Elena Gómez-Díaz
Mar 4, 2020·BMC Infectious Diseases·Apoorva VenkateshSanjeeva Srivastava
Nov 9, 2019·Biological Reviews of the Cambridge Philosophical Society·Rowena E Martin
Oct 8, 2020·Biomolecules·Maryia Karpiyevich, Katerina Artavanis-Tsakonas
Jul 16, 2021·Frontiers in Cellular and Infection Microbiology·Guodong NiuJun Li

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