Plasmodium-specific antibodies block in vivo parasite growth without clearing infected red blood cells

PLoS Pathogens
Jasmin AkterAshraful Haque

Abstract

Plasmodium parasites invade and multiply inside red blood cells (RBC). Through a cycle of maturation, asexual replication, rupture and release of multiple infective merozoites, parasitised RBC (pRBC) can reach very high numbers in vivo, a process that correlates with disease severity in humans and experimental animals. Thus, controlling pRBC numbers can prevent or ameliorate malaria. In endemic regions, circulating parasite-specific antibodies associate with immunity to high parasitemia. Although in vitro assays reveal that protective antibodies could control pRBC via multiple mechanisms, in vivo assessment of antibody function remains challenging. Here, we employed two mouse models of antibody-mediated immunity to malaria, P. yoelii 17XNL and P. chabaudi chabaudi AS infection, to study infection-induced, parasite-specific antibody function in vivo. By tracking a single generation of pRBC, we tested the hypothesis that parasite-specific antibodies accelerate pRBC clearance. Though strongly protective against homologous re-challenge, parasite-specific IgG did not alter the rate of pRBC clearance, even in the presence of ongoing, systemic inflammation. Instead, antibodies prevented parasites progressing from one generation of RBC...Continue Reading

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Citations

Sep 27, 2019·Immunological Reviews·Liriye KurtovicJames G Beeson
Nov 15, 2019·HemaSphere·Francesca Vinchi, Cheryl A Lobo
Mar 9, 2021·Microbes and Infection·Kai J RogersNoah S Butler
Apr 29, 2021·Journal of the Royal Society, Interface·Madeline A E PetersNicole Mideo
May 4, 2021·Frontiers in Cellular and Infection Microbiology·Takaaki YuguchiHitoshi Otsuki
Jun 14, 2021·Trends in Parasitology·Bénédicte GnangnonCaroline O Buckee
Aug 21, 2021·Frontiers in Cellular and Infection Microbiology·Vitomir DjokicNikhat Parveen

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Methods Mentioned

BETA
flow cytometry
FACS
ELISA
flow-cytometry

Software Mentioned

Py
FlowJo
MATLAB
Gen5
GraphPad Prism

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