Plasmodium vivax merozoite surface protein PvMSP-3 beta is radically polymorphic through mutation and large insertions and deletions

Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases
Julian C RaynerJ W Barnwell

Abstract

Plasmodium vivax causes the majority of malaria outside of sub-Saharan Africa and is an important burden for affected countries. The recent spread of drug-resistant P. vivax strains in these countries has led to renewed pressure for the development of a P. vivax vaccine. The complex life cycle of P. vivax presents many potential vaccine targets, but among the most promising candidates are subunits of the surface coat that surrounds the merozoite, the parasite stage that infects erythrocytes and initiates much of the pathology of malaria. Although the genes for several constituents of the P. vivax surface coat have now been cloned and sequenced, little is known about the extent to which these proteins vary between populations, an important consideration in vaccine development. The merozoite surface protein MSP-3beta is a member of a family of related merozoite surface proteins, all of which contain a central alanine-rich domain that is predicted to form a coiled-coil tertiary structure. We have sequenced the PvMSP-3 beta gene from P. vivax isolates originating in Central and South America, Asia and the Pacific. In this first assessment of PvMSP-3 beta variation between populations, we discovered widespread and significant divers...Continue Reading

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Citations

Aug 16, 2006·Malaria Journal·Jung-Ryong KimSasithon Pukrittayakamee
Feb 20, 2009·Malaria Journal·Mary R Galinski, John W Barnwell
Mar 5, 2013·PloS One·Amanda R BitencourtIrene S Soares
Feb 5, 2011·The American Journal of Tropical Medicine and Hygiene·Yue WangEun-Taek Han
Mar 31, 2011·Tropical Medicine & International Health : TM & IH·Kanchana RungsihirunratKesara Na-Bangchang
Oct 9, 2014·Malaria Research and Treatment·D D RajgorN A Kshirsagar
Jun 1, 2011·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Daibin ZhongBin Zheng
Oct 23, 2016·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Bhavna GuptaLiwang Cui
Jun 15, 2007·Memórias do Instituto Oswaldo Cruz·Wanessa Christina de Souza-NeirasRicardo Luiz Dantas Machado
Sep 25, 2016·Malaria Journal·Anju VermaNeena Valecha
Jan 30, 2020·Malaria Journal·Vivek Bhakta MathemaMallika Imwong
Mar 1, 2017·Frontiers in Immunology·Carolina LópezManuel A Patarroyo

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