Plasmonic-Based Electrochemical Impedance Imaging of Electrical Activities in Single Cells

Angewandte Chemie
Xianwei LiuNongjian Tao

Abstract

Studying electrical activities in cells, such as action potential and its propagation in neurons, requires a sensitive and non-invasive analytical tool that can image local electrical signals with high spatial and temporal resolutions. Here we report a plasmonic-based electrochemical impedance imaging technique to study transient electrical activities in single cells. The technique is based on the conversion of the electrical signal into a plasmonic signal, which is imaged optically without labels. We demonstrate imaging of the fast initiation and propagation of action potential within single neurons, and validate the imaging technique with the traditional patch clamp technique. We anticipate that the plasmonic imaging technique will contribute to the study of electrical activities in various cellular processes.

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Citations

Feb 8, 2019·Angewandte Chemie·Chen QianXian-Wei Liu
Mar 24, 2020·Chemical Communications : Chem Comm·Ling LiWeihua Hu
Jun 14, 2018·Chemical Science·Tao LiuWei Wang
Feb 9, 2019·Optics Express·Carlos Macias-RomeroSylvie Roke
Sep 23, 2020·Nature Methods·Pengfei ZhangNongjian Tao
Apr 14, 2018·Analytical and Bioanalytical Chemistry·Yu-Wen Su, Wei Wang
Jul 8, 2020·Proceedings of the National Academy of Sciences of the United States of America·Felix S AlfonsoBianxiao Cui
Jan 23, 2021·Light, Science & Applications·Cristina PolonschiiEugen Gheorghiu
Feb 11, 2021·Environmental Science & Technology·Yi-Nan LiuXian-Wei Liu
May 28, 2020·ACS Sensors·Fenni ZhangNongjian Tao
Jul 1, 2021·Journal of the American Chemical Society·Yuecheng ZhouBianxiao Cui
Jul 31, 2018·Journal of the American Chemical Society·Jing LiErkang Wang
Nov 21, 2019·Analytical Chemistry·Xiao Ying GuCheng Zhi Huang
Apr 16, 2019·Analytical Chemistry·Fan WuSteffi Krause

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