Plasmonic nano-aperture label-free imaging (PANORAMA).

Nature Communications
Nareg OhannesianWei-Chuan Shih

Abstract

Label-free optical imaging of nanoscale objects faces fundamental challenges. Techniques based on propagating surface plasmon resonance (SPR) and localized surface plasmon resonance (LSPR) have shown promises. However, challenges remain to achieve diffraction-limited resolution and better surface localization in SPR imaging. LSPR imaging with dark-field microscopy on metallic nanostructures suffers from low light throughput and insufficient imaging capacity. Here we show ultra-near-field index modulated PlAsmonic NanO-apeRture lAbel-free iMAging (PANORAMA) which uniquely relies on unscattered light to detect sub-100 nm dielectric nanoparticles. PANORAMA provides diffraction-limited resolution, higher surface sensitivity, and wide-field imaging with dense spatial sampling. Its system is identical to a standard bright-field microscope with a lamp and a camera - no laser or interferometry is needed. In a parallel fashion, PANORAMA can detect, count and size individual dielectric nanoparticles beyond 25 nm, and dynamically monitor their distance to the plasmonic surface at millisecond timescale.

References

Aug 12, 2006·Science·Eric BetzigHarald F Hess
Oct 28, 2006·Annual Review of Physical Chemistry·Katherine A Willets, Richard P Van Duyne
Oct 11, 2008·Nano Letters·Alexandre DmitrievDuncan S Sutherland
Mar 13, 2010·Science·Xiaonan ShanNongjian Tao
Aug 28, 2012·Nature Nanotechnology·Xiaonan ShanNongjian Tao
May 20, 2014·Journal of Nanoparticle Research : an Interdisciplinary Forum for Nanoscale Science and Technology·Thorsten WagnerMartin Wiemann
Oct 4, 2014·Science·Philip D HowesMolly M Stevens
Mar 21, 2015·ACS Nano·Pengyu ChenKatsuo Kurabayashi
Nov 18, 2016·Scientific Reports·George G DaaboulMarcella Chiari
Dec 15, 2016·Nano Letters·Joachim FritzscheChristoph Langhammer
Jul 22, 2017·The Journal of Physical Chemistry Letters·Tokuhisa KawawakiTetsu Tatsuma
Feb 10, 2018·Science Advances·Boxuan ShenJ Jussi Toppari
May 29, 2018·Nature Methods·Dayong JinAntoine M van Oijen
Aug 25, 2018·PloS One·Deepa RaghuMarc P Raphael
Sep 1, 2018·Light, Science & Applications·Srdjan S AćimovićMikael Käll
Sep 27, 2018·Proceedings of the National Academy of Sciences of the United States of America·Yuting YangHui Yu
Mar 7, 2019·Light, Science & Applications·Joseph W NelsonNathan C Lindquist
Sep 1, 2017·Nanoscale Horizons : the Home for Rapid Reports of Exceptional Significance in Nanoscience and Nanotechnolgy·Fusheng ZhaoWei-Chuan Shih

❮ Previous
Next ❯

Methods Mentioned

BETA
optical microscopy
optical diffraction
flow cytometry
surface plasmon resonance
light scattering
imaging techniques
sizing
imaging technique

Software Mentioned

iSCAT
PANAROMA
PANORAMA
SPRI
PANOMARA
IRIS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Procare : Das Forbildungsmagazin Fur Pflegeberufe
Wiener Klinisches Magazin : Beilage Zur Wiener Klinischen Wochenschrift
HNO-Nachrichten
Ressort Hno
Pädiatrie und Pädologie
HNO-Nachrichten
Redaktion Facharztmagazine
© 2021 Meta ULC. All rights reserved