Plastic changes in the cholinergic innervation of the rat cerebral cortex after unilateral lesion of the nucleus basalis with alpha-amino-3-OH-4-isoxozole propionic acid (AMPA): effects of basal forebrain transplants into neocortex

Brain Research Bulletin
M R CalaminiciJ D Stephenson

Abstract

Unilateral AMPA lesions of the nucleus basalis magnocellularis (nbm) produced a nearly complete loss of cholinergic markers in the ipsilateral frontal and parietal cortices with no recovery at 6 months. The loss was associated with compensatory increases in AChE-positive fibre density in the contralateral cortex, in ipsilateral cortical regions not receiving their cholinergic innervation from the nbm and in the size of cholinergic magnocellular neurones in the contralateral nbm. The hypertrophy and increase in AChE-positive fibre density were apparent at 4-6 weeks after lesion and increased with time. Cholinergic transplants to cholinergically deafferented cortex prevented development of the compensatory increases in AChE-positive fibre density and restored AChE-positive fibre density and ChAT activity to control levels in ipsilateral cholinergically deafferented regions, partially after 6-8 weeks and completely after 6 months. In contrast, when cholinergic grafts were placed into unlesioned cortex, axonal outgrowth was localized to the vicinity of the transplant and did not develop with time. These results support the concept that vacant synapses promote and direct axonal outgrowth from transplanted neurones and that grafted c...Continue Reading

References

Sep 1, 1976·Brain : a Journal of Neurology·D M BowenA N Davison
Jan 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·T F Freund, V Meskenaite
Jan 1, 1991·Progress in Neurobiology·N J Woolf
Apr 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·O G NilssonA Björklund
May 1, 1988·Neuroscience·F P EckensteinJ Quinn
Oct 1, 1986·Physiology & Behavior·J P Kroon, A L Riley
Jun 1, 1987·Journal of the Neurological Sciences·J O RinneU K Rinne
Jan 1, 1980·Neuroscience·I W ChubbG H White

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Citations

Jun 5, 2003·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·A K AgrawalP K Seth

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