PMID: 6595463Sep 1, 1984

Plastic filing from dialysis tubing induces prostanoid release from macrophages

Kidney International
J BommerE Ritz

Abstract

Multiorgan, abnormalities in dialysis patients (for example, hepatosplenomegaly, granulomatous hepatitis, cytopenia from hypersplenism) have recently been ascribed to the loading of macrophages (MO) with silicone particles released from the pump segment of dialysis tubing. In the present study, the effect of chronic intravenous or intraperitoneal loading of rats with silicone, polyvinylchloride (PVC) and polyurethane (PU) particles on arachidonic acid metabolism of peritoneal MO and splenic cells was examined in vitro. Intravenous injections of silicone, PVC, or PU particles caused accumulation of the material within the lysosomes of MO of spleen, liver, and lung. Spontaneous release of prostaglandin E2 (PGE2) and thromboxane B2 (TXB2) was significantly increased in peritoneal MO of rats injected with silicone, PVC, or PU (Control: 4.27 +/- 0.85 ng PGE2/ml/24 hr; silicone 51.9 +/- 13.2; PVC 57.5 +/- 10.6; PU 28.8 +/- 2.3). Zymosan or LPS stimulated PGE2 release from control MO, but caused no consistent further elevation of high basal PGE2 release from MO after particle loading. Furthermore, increased spontaneous and stimulated TXB2 release was also observed in spleen cells of rats given intravenous injection of silicone particl...Continue Reading

References

Jul 22, 1978·British Medical Journal·P AljamaD N Kerr
Sep 1, 1977·Prostaglandins·F CotteeJ R Vane
Oct 20, 1975·JAMA : the Journal of the American Medical Association·R Ellenbogen, L Rubin
Jan 1, 1973·Transactions - American Society for Artificial Internal Organs·Robert M LindsayA C Kennedy
Apr 1, 1967·Plastic and Reconstructive Surgery·T D ReesG A Hawthorne
Mar 31, 1983·The New England Journal of Medicine·J ChastreC Gibert
Jan 21, 1982·The New England Journal of Medicine·E A Friedman, A P Lundin
Oct 1, 1980·Kidney International·A I JacobJ J Bourgoignie

Citations

Nov 1, 1994·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·S H YoshidaM E Gershwin
Feb 1, 1986·Artificial Organs·S Ringoir, R Vanholder
Dec 1, 1987·Artificial Organs·J L Funck-Brentano
Jan 1, 1988·Biomaterials, Artificial Cells, and Artificial Organs·S CaiazzaG Donelli
Dec 10, 1991·Clinical Materials·R Vanholder
May 1, 1990·Prostaglandins, Leukotrienes, and Essential Fatty Acids·M B Starling, J M Neutze
Nov 1, 1988·Diabetic Medicine : a Journal of the British Diabetic Association·R N Baldwin
Sep 15, 1986·Klinische Wochenschrift·J Bommer
Dec 1, 1989·Artificial Organs·R Vanholder, S Ringoir

Related Concepts

Hemodialysis
Injectables
Intubation
Renal Dialysis Machine
Macrophage
Electron Microscopy
Greater Sac of Peritoneum
Plastics
Spandex
Vinylite

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