PMID: 1203666Dec 6, 1975Paper

Plastic isolators for treatment of acute leukaemia patients under "germ-free" conditions

British Medical Journal
P C TrexlerH Gaya

Abstract

A gnotobiotic isolation system based on those developed in veterinary research has been constructed for hospital use. Fifteen patients with leukaemia and neutropenia spent a total of 110 weeks in plastic isolators, and none acquired any infection. Endogenous flora was effectively suppressed by topical antiseptics and gastrointestinal decontamination effected with nonabsorbable antibiotics. The isolator system was acceptable to patients and staff and much cheaper than the use of sterile rooms. Other advantages of the system are portability, easy storage, and use on ordinary open wards without prejudice to the microbiological protection afforded. It is as yet uncertain whether protective environments of this type will substantially improve the outcome of treatment for the acute leukaemias.

References

May 22, 1971·Lancet·J LynchH E Kay
May 26, 1973·The Veterinary Record·A J DrummondJ E Cox
Jan 2, 1971·The Veterinary Record·P C Trexler
May 1, 1964·American Journal of Surgery·S M LEVENSONE J PULASKI

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Citations

Jul 1, 1977·Archives of Disease in Childhood·J G WatsonR G Smith
Feb 12, 1977·British Medical Journal·A J BarrettJ G Watson
Aug 27, 1977·British Medical Journal·P C TrexlerB Evans
May 1, 1983·Journal of Clinical Pathology·P C Trexler, A M Gilmour
Sep 1, 1976·Postgraduate Medical Journal·J M GoldmanA M Gordon
Sep 1, 1983·The Journal of Hospital Infection·G J HarperB A Page-Roberts
Mar 1, 1980·The Journal of Hospital Infection·S Selwyn
Sep 22, 2016·The Journal of Infectious Diseases·Mark G KortepeterTheodore J Cieslak
May 21, 2003·Critical Care Nursing Clinics of North America·LeRoy A Marklund
Jul 1, 1983·JPEN. Journal of Parenteral and Enteral Nutrition·S N Aker, C L Cheney
Nov 1, 1977·Langenbecks Archiv für Chirurgie·H P Seeliger, U Vögtle-Junkert
Jan 1, 2016·Current Treatment Options in Infectious Diseases·Theodore J Cieslak, Mark G Kortepeter
Jan 1, 1979·Clinical and Laboratory Haematology·A J Barrett

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