Plastic Scintillator-Based Microfluidic Devices for Miniaturized Detection of Positron Emission Tomography Radiopharmaceuticals

Chemistry : a European Journal
Mark D TarnStephen J Archibald

Abstract

A miniaturized radio-HPLC detector has been developed comprising a microfluidic device fabricated from plastic scintillator in combination with a silicon photomultiplier light sensor, and tested with samples containing a positron-emitting radionuclide, [18 F]fluoride. This cost-effective, small footprint analytical tool is ideal for incorporation into integrated quality control systems for the testing of positron emission tomography (PET) radiopharmaceuticals to good manufacturing practice (GMP) standards.

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Citations

Sep 6, 2019·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Karla-Anne KnappH Charles Manning
Nov 11, 2020·Analytical Chemistry·Simon F BerlandaPetra S Dittrich
May 21, 2020·Molecular Pharmaceutics·Louis Allott, Eric O Aboagye
Jan 29, 2020·Analytical Chemistry·Jason JonesR Michael van Dam

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