Plasticity and Susceptibility of Brain Morphometry Alterations to Insufficient Sleep

Frontiers in Psychiatry
Xi-Jian DaiYang Zhan

Abstract

Background: Insufficient sleep is common in daily life and can lead to cognitive impairment. Sleep disturbance also exists in neuropsychiatric diseases. However, whether and how acute and chronic sleep loss affect brain morphology remain largely unknown. Methods: We used voxel-based morphology method to study the brain structural changes during sleep deprivation (SD) at six time points of rested wakefulness, 20, 24, 32, 36 h SD, and after one night sleep in 22 healthy subjects, and in 39 patients with chronic primary insomnia relative to 39 status-matched good sleepers. Attention network and spatial memory tests were performed at each SD time point in the SD Procedure. The longitudinal data were analyzed using one-way repeated measures ANOVA, and post-hoc analysis was used to determine the between-group differences. Results: Acute SD is associated with widespread gray matter volume (GMV) changes in the thalamus, cerebellum, insula and parietal cortex. Insomnia is associated with increased GMV in temporal cortex, insula and cerebellum. Acute SD is associated with brain atrophy and as SD hours prolong more areas show reduced GMV, and after one night sleep the brain atrophy is restored and replaced by increased GMV in brain areas....Continue Reading

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Citations

Sep 11, 2019·Brain Imaging and Behavior·Thomas RitzE Sherwood Brown
Feb 9, 2021·Journal of Sleep Research·LiQin ShengPingLei Pan
Feb 27, 2021·Frontiers in Neurology·Adam C RaikesWilliam D S Killgore
Dec 19, 2020·Biochemical Pharmacology·Whitney Stee, Philippe Peigneux
Aug 2, 2021·The Journal of Nervous and Mental Disease·Hui ZhangQi Guo

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BETA
imaging techniques
SMA

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Fitbit Flex
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