Plasticity based on compensatory effector use in the association but not primary sensorimotor cortex of people born without hands

Proceedings of the National Academy of Sciences of the United States of America
Ella Striem-AmitAlfonso Caramazza

Abstract

What forces direct brain organization and its plasticity? When brain regions are deprived of their input, which regions reorganize based on compensation for the disability and experience, and which regions show topographically constrained plasticity? People born without hands activate their primary sensorimotor hand region while moving body parts used to compensate for this disability (e.g., their feet). This was taken to suggest a neural organization based on functions, such as performing manual-like dexterous actions, rather than on body parts, in primary sensorimotor cortex. We tested the selectivity for the compensatory body parts in the primary and association sensorimotor cortex of people born without hands (dysplasic individuals). Despite clear compensatory foot use, the primary sensorimotor hand area in the dysplasic subjects showed preference for adjacent body parts that are not compensatorily used as effectors. This suggests that function-based organization, proposed for congenital blindness and deafness, does not apply to the primary sensorimotor cortex deprivation in dysplasia. These findings stress the roles of neuroanatomical constraints like topographical proximity and connectivity in determining the functional d...Continue Reading

References

Nov 13, 1992·Science·V S RamachandranM Stewart
Aug 24, 1990·Neuroscience Letters·E J HallR N Lemon
Oct 1, 1995·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·B BiswalJ S Hyde
Aug 29, 1996·Nature·S GeyerP E Roland
Jan 1, 1997·Somatosensory & Motor Research·M H Schieber, R K Deuel
Mar 26, 1999·Trends in Neurosciences·J P Rauschecker
Jul 1, 1999·NeuroImage·K J FristonK J Worsley
Jul 1, 1999·NeuroImage·S GeyerK Zilles
Jun 9, 2000·Annual Review of Neuroscience·J N Sanes, J P Donoghue
Jul 17, 2001·The European Journal of Neuroscience·P FattoriC Galletti
Oct 24, 2001·Brain : a Journal of Neurology·M LotzeN Birbaumer
Nov 8, 2001·Journal of Neurophysiology·M H Schieber
Jun 13, 2003·Journal of Neurophysiology·A R DickinsonL H Snyder
Oct 8, 2004·Journal of Neurophysiology·M Cornelia StoeckelAlfons Schnitzler
Jan 28, 2005·The European Journal of Neuroscience·M Cornelia StoeckelRüdiger J Seitz
Jul 14, 2005·Journal of Anatomy·Christian Grefkes, Gereon R Fink
Nov 8, 2005·Current Opinion in Neurobiology·Leonardo Fogassi, Giuseppe Luppino
May 11, 2006·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·James W Lewis
Sep 18, 2007·NeuroImage·K AmuntsK Zilles
Jun 24, 2008·Brain : a Journal of Neurology·K MacIverT Nurmikko
Aug 8, 2008·Journal of Neurophysiology·Jeffrey D MeierMichael S A Graziano
Oct 24, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Neeraj JainJon H Kaas
Jan 24, 2009·Proceedings of the National Academy of Sciences of the United States of America·M Cornelia StoeckelCathrin M Buetefisch
Mar 19, 2009·Psychonomic Bulletin & Review·Jeffrey N RouderGeoffrey Iverson
Apr 9, 2009·Brain : a Journal of Neurology·G Goldenberg, J Spatt
Apr 10, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jason P GallivanJody C Culham
Sep 18, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·R PeetersG A Orban
Jan 5, 2010·Nature Reviews. Neuroscience·Karl Zilles, Katrin Amunts
Jan 9, 2010·NeuroImage·Svenja CaspersSimon B Eickhoff
Feb 15, 2011·Trends in Cognitive Sciences·Bradford Z Mahon, Alfonso Caramazza
Apr 5, 2011·Annual Review of Neuroscience·J Douglas CrawfordW Pieter Medendorp
Jul 1, 2011·Frontiers in Neuroanatomy·Jon H KaasIwona Stepniewska
Nov 25, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jason P GallivanJody C Culham
Aug 1, 2012·The European Journal of Neuroscience·Lars StrotherTutis Vilis
Feb 1, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jason P GallivanJody C Culham
Mar 5, 2013·Neuroscience and Biobehavioral Reviews·Laurent RenierJosef P Rauschecker
Nov 14, 2013·ELife·Tamar R MakinHeidi Johansen-Berg
Dec 12, 2013·European Journal of Pain : EJP·J FoellH Flor

❮ Previous
Next ❯

Citations

Jun 9, 2020·PLoS Biology·Roni O Maimon Mor, Tamar R Makin
Sep 1, 2018·Cerebral Cortex·Gilles VannuscorpsAlfonso Caramazza
Jul 11, 2020·Proceedings of the National Academy of Sciences of the United States of America·Adarsh KumarPratik K Mutha
Jan 9, 2021·Journal of Cognitive Neuroscience·Gilles VannuscorpsAlfonso Caramazza
Jan 18, 2021·Current Opinion in Neurobiology·Artur Kania
Oct 28, 2020·Proceedings of the National Academy of Sciences of the United States of America·Yuqi LiuElla Striem-Amit
Nov 24, 2020·Open Mind : Discoveries in Cognitive Science·Erez FreudJacqueline C Snow
Nov 29, 2020·Current Opinion in Neurobiology·Dollyane Muret, Tamar R Makin
Aug 11, 2021·Neural Plasticity·Daniel S ScholzEckart Altenmüller
Nov 20, 2021·The European Journal of Neuroscience·Bia Lima RamalhoKaren T Reilly

❮ Previous
Next ❯

Methods Mentioned

BETA
amputation

Software Mentioned

Brain Voyager QX
aIPS
Brain Voyager
Brain Innovation

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Proceedings of the National Academy of Sciences of the United States of America
Ella Striem-AmitAlfonso Caramazza
The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Stefania BracciMarius V Peelen
© 2022 Meta ULC. All rights reserved