Plasticity from muscle to brain

Progress in Neurobiology
J R Wolpaw, Jonathan S Carp

Abstract

Recognition that the entire central nervous system (CNS) is highly plastic, and that it changes continually throughout life, is a relatively new development. Until very recently, neuroscience has been dominated by the belief that the nervous system is hardwired and changes at only a few selected sites and by only a few mechanisms. Thus, it is particularly remarkable that Sir John Eccles, almost from the start of his long career nearly 80 years ago, focused repeatedly and productively on plasticity of many different kinds and in many different locations. He began with muscles, exploring their developmental plasticity and the functional effects of the level of motor unit activity and of cross-reinnervation. He moved into the spinal cord to study the effects of axotomy on motoneuron properties and the immediate and persistent functional effects of repetitive afferent stimulation. In work that combined these two areas, Eccles explored the influences of motoneurons and their muscle fibers on one another. He studied extensively simple spinal reflexes, especially stretch reflexes, exploring plasticity in these reflex pathways during development and in response to experimental manipulations of activity and innervation. In subsequent de...Continue Reading

References

Apr 26, 1977·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·A J Buller, R Pope
May 1, 1979·Journal of Neurophysiology·S G Nelson, L M Mendell
Jun 1, 1979·The Journal of Physiology·R GallegoW D Snider
Feb 15, 1979·European Journal of Applied Physiology and Occupational Physiology·P RochcongarR Le Bars
Aug 1, 1979·The Journal of Physiology·B Gustafsson
May 1, 1977·Journal of Neurophysiology·C B Heyer, R Llinás
Jul 1, 1975·Journal of Neurophysiology·J C EcclesH Táboríková
Apr 1, 1992·Journal of Applied Physiology·R B SteinM Belanger
Jul 1, 1992·The American Journal of Physiology·V J CaiozzoK M Baldwin
Jan 1, 1992·Reviews of Physiology, Biochemistry and Pharmacology·D Pette, G Vrbová
Jan 1, 1992·Muscle & Nerve·S C GrahamV R Edgerton
Jun 1, 1991·International Journal of Sports Medicine·D M KocejaG Kamen
Sep 1, 1990·The American Journal of Physiology·B JiangV R Edgerton
Aug 1, 1990·Journal of Neurophysiology·A Mailis, P Ashby
Jan 1, 1990·Progress in Neurobiology·M J Titmus, D S Faber
Jan 1, 1990·European Journal of Applied Physiology and Occupational Physiology·A CasabonaV Perciavalle
Mar 1, 1990·Journal of Neurology, Neurosurgery, and Psychiatry·A F ThilmannE Garms
Oct 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·E SernagorR Werman
Nov 6, 1989·Neuroscience Letters·M L EvattR L Segal
Mar 1, 1989·Journal of Neurophysiology·J R Wolpaw, C L Lee
Aug 1, 1986·Developmental Medicine and Child Neurology·B M MyklebustG C Agarwal
Feb 1, 1987·Journal of Neurophysiology·J R Wolpaw
Jun 1, 1987·Experimental Neurology·A M WiniarskiV R Edgerton

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Citations

Sep 14, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Andrew M TanJohn H Martin
Feb 1, 2011·Pflügers Archiv : European journal of physiology·Tian LiChristopher S von Bartheld
Jul 26, 2011·Brain Research·Douglas G Stuart, Robert M Brownstone
Apr 29, 2011·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Mar CortesDylan J Edwards
Apr 14, 2009·Neurobiology of Learning and Memory·P De BartoloL Petrosini
Oct 14, 2011·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·A FattahR M Zuker
May 6, 2006·Progress in Neurobiology·Benjamin Libet
Apr 25, 2006·Progress in Neurobiology·Douglas G Stuart, Patricia A Pierce
May 2, 2006·Progress in Neurobiology·Robert E Burke
May 3, 2006·Progress in Neurobiology·William D Willis
Jan 8, 2011·Gait & Posture·Yung-Sheng Chen, Shi Zhou
Feb 10, 2009·Molecular Genetics and Metabolism·Marieke HoeksmaFrancjan J van Spronsen
Jan 26, 2007·Journal of Neurophysiology·Sabine MeunierMark Hallett
May 25, 2012·Journal of Neurophysiology·Jean-Charles LamyMaxwell Boakye
Oct 25, 2011·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Yury Shtyrov
Apr 23, 2021·Journal of Neuroengineering and Rehabilitation·Min Hyong KohChristopher J Hasson

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