Plasticity in D1-like receptor expression is associated with different components of cognitive processes.

PloS One
Christina HeroldOnur Güntürkün

Abstract

Dopamine D1-like receptors consist of D1 (D1A) and D5 (D1B) receptors and play a key role in working memory. However, their possibly differential contribution to working memory is unclear. We combined a working memory training protocol with a stepwise increase of cognitive subcomponents and real-time RT-PCR analysis of dopamine receptor expression in pigeons to identify molecular changes that accompany training of isolated cognitive subfunctions. In birds, the D1-like receptor family is extended and consists of the D1A, D1B, and D1D receptors. Our data show that D1B receptor plasticity follows a training that includes active mental maintenance of information, whereas D1A and D1D receptor plasticity in addition accompanies learning of stimulus-response associations. Plasticity of D1-like receptors plays no role for processes like response selection and stimulus discrimination. None of the tasks altered D2 receptor expression. Our study shows that different cognitive components of working memory training have distinguishable effects on D1-like receptor expression.

References

Feb 22, 1991·Science·T Sawaguchi, P S Goldman-Rakic
Nov 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·P S Goldman-RakicM Geffard
Feb 1, 1989·Journal of Neurophysiology·S FunahashiP S Goldman-Rakic
Nov 1, 1994·Neuroscience Research·S Funahashi, K Kubota
Jul 1, 1994·Trends in Pharmacological Sciences·P Seeman, H H Van Tol
Nov 14, 1997·Journal of Neurophysiology·M WatanabeK Hikosaka
Nov 19, 1997·The Journal of Comparative Neurology·R SchnabelK Braun
Feb 11, 1998·Physiological Reviews·C MissaleM G Caron
Dec 9, 1998·Proceedings of the National Academy of Sciences of the United States of America·G RainerE K Miller
Aug 27, 1999·Progress in Neurobiology·D DurstewitzO Güntürkün
Dec 11, 1999·European Journal of Pharmacology·M El-GhundiS R George
Sep 30, 2000·Brain Research. Brain Research Reviews·W J Smeets, A González
Dec 29, 2000·Nature Neuroscience·D DurstewitzT J Sejnowski
Oct 18, 2002·Neuron·Wolfram Schultz
Nov 5, 2003·Biology of the Cell·Sophie CallierPhilippe Vernier
Jan 16, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Anthony G PhillipsStan B Floresco
Apr 30, 2004·The Journal of Comparative Neurology·Anton ReinerUNKNOWN Avian Brain Nomenclature Forum
Sep 24, 2004·Progress in Neurobiology·Jeremy K Seamans, Charles R Yang
Feb 3, 2005·Nature Reviews. Neuroscience·Erich D JarvisUNKNOWN Avian Brain Nomenclature Consortium
Feb 19, 2005·Science·Christian K MachensCarlos D Brody
Jun 9, 2005·PLoS Biology·Jonas Rose, Michael Colombo
Sep 8, 2005·Brain Research Bulletin·A Reiner
Nov 3, 2005·Current Opinion in Neurobiology·Onur Güntürkün
Dec 6, 2005·Neuroscience·D Durstewitz, J K Seamans
Jan 6, 2007·Brain and Cognition·Stacy A Castner, Graham V Williams
Feb 6, 2007·Nature Neuroscience·Susheel VijayraghavanAmy F T Arnsten
May 18, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Giselle M PetzingerMichael W Jakowec
Mar 21, 2008·Biochemical Pharmacology·Wei-Dong YaoJingping Zhang

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Citations

Dec 1, 2012·Molecular Biology and Evolution·Kei YamamotoPhilippe Vernier
Jan 8, 2013·Behavioural Brain Research·Luke K SherrillJoshua M Gulley
Mar 6, 2016·Trends in Cognitive Sciences·Onur Güntürkün, Thomas Bugnyar
May 17, 2018·Acta neurologica Belgica·Mohammad NasehiMohammad-Reza Zarrindast
Apr 8, 2020·The Journal of General Physiology·Clara Inés McCarthyJesica Raingo
Mar 14, 2018·Learning & Behavior·Onur GüntürkünRoland Pusch
Oct 25, 2017·The Journal of Comparative Neurology·Christina HeroldKarl Zilles
Sep 20, 2020·Nature Communications·Mehdi BehrooziOnur Güntürkün

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Datasets Mentioned

BETA
EU190463

Methods Mentioned

BETA
PCR
electrophoresis

Software Mentioned

BLAST®
Statistica

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