PMID: 7536748Apr 1, 1995Paper

Plasticity in epithelial cell phenotype: modulation by expression of different cadherin cell adhesion molecules

The Journal of Cell Biology
J A MarrsW J Nelson

Abstract

A primary function of cadherins is to regulate cell adhesion. Here, we demonstrate a broader function of cadherins in the differentiation of specialized epithelial cell phenotypes. In situ, the rat retinal pigment epithelium (RPE) forms cell-cell contacts within its monolayer, and at the apical membrane with the neural retina; Na+, K(+)-ATPase and the membrane cytoskeleton are restricted to the apical membrane. In vitro, RPE cells (RPE-J cell line) express an endogenous cadherin, form adherens junctions and a tight monolayer, but Na+,K(+)-ATPase is localized to both apical and basal-lateral membranes. Expression of E-cadherin in RPE-J cells results in restriction and accumulation of both Na+,K(+)-ATPase and the membrane cytoskeleton at the lateral membrane; these changes correlate with the synthesis of a different ankyrin isoform. In contrast to both RPE in situ and RPE-J cells that do not form desmosomes, E-cadherin expression in RPE-J cells induces accumulation of desmoglein mRNA, and assembly of desmosome-keratin complexes at cell-cell contacts. These results demonstrate that cadherins directly affect epithelial cell phenotype by remodeling the distributions of constitutively expressed proteins and by induced accumulation of...Continue Reading

References

Jan 1, 1992·Cold Spring Harbor Symposia on Quantitative Biology·L H RomerC E Turner
Aug 25, 1992·Proceedings of the National Academy of Sciences of the United States of America·E D AvnerW J Nelson
Jan 1, 1992·Cold Spring Harbor Symposia on Quantitative Biology·F S Walsh, P Doherty
Jan 1, 1992·Annual Review of Cell Biology·E Rodriguez-Boulan, S K Powell
May 1, 1992·Cell·B M Gumbiner
Jun 1, 1992·Seminars in Cell Biology·R Kemler
Jan 1, 1991·Annual Review of Biochemistry·G M Edelman, K L Crossin
May 1, 1991·The Journal of Cell Biology·E W NapolitanoL F Reichardt
Jan 1, 1990·Cold Spring Harbor Symposia on Quantitative Biology·M TakeichiA Nagafuchi
Jan 1, 1990·Annual Review of Cell Biology·M A SchwarzW W Franke
Aug 18, 1989·Science·E Rodriguez-Boulan, W J Nelson
Dec 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·A Le BivicE Rodriguez-Boulan
Mar 1, 1989·The Journal of Membrane Biology·M SargiacomoE Rodriguez-Boulan
Sep 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·D R FriedlanderG M Edelman
Jan 1, 1986·Annual Review of Cell Biology·G M Edelman
Jan 1, 1985·Annual Review of Biochemistry·G M Edelman
Sep 1, 1973·The Journal of Cell Biology·P M QuintonJ M Tormey
Jan 1, 1984·The Journal of Membrane Biology·W Almers, C Stirling
Jul 1, 1994·The Journal of Cell Biology·W M Brieher, B M Gumbiner
Jun 2, 1994·The New England Journal of Medicine·E M Fish, B A Molitoris
Jan 4, 1994·Proceedings of the National Academy of Sciences of the United States of America·M S Steinberg, M Takeichi
Jan 1, 1994·Developmental Biology·C Murphy-ErdoshL F Reichardt
Apr 1, 1993·The Journal of Cell Biology·D GundersenE Rodriguez-Boulan

❮ Previous
Next ❯

Citations

Jun 9, 1999·International Journal of Cancer. Journal International Du Cancer·L A GiroldiJ A Schalken
Aug 1, 1997·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·S M Frisch
Jul 12, 2002·Developmental Dynamics : an Official Publication of the American Association of Anatomists·A Sue MenkoMaria A Kukuruzinska
Feb 21, 2006·Cell and Tissue Research·Ruei-Zeng LinHwan-You Chang
Jun 1, 2011·Journal of Ocular Biology, Diseases, and Informatics·Hui-Zhuo XuYun-Zheng Le
Oct 1, 1996·Current Opinion in Cell Biology·D GarrodA North
Oct 1, 1996·Current Opinion in Cell Biology·O HuberR Kemler
Oct 6, 1999·Current Opinion in Cell Biology·M S Steinberg, P M McNutt
Dec 12, 2001·Traffic·A D Marmorstein
Feb 1, 1996·The Journal of Cell Biology·A K RajasekaranE Rodriguez-Boulan
Jan 25, 2013·Molecular Biology of the Cell·Moorthy KrishnanJames R Goldenring
Apr 24, 2012·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Kristina EnelingAlejandro M Bertorello
Mar 20, 1998·American Journal of Reproductive Immunology : AJRI·C D MacCalmanG T Chen
Mar 1, 2000·Molecular Pathology : MP·V M Braga
Jan 1, 1997·Annual Review of Cell and Developmental Biology·A S YapB M Gumbiner
Apr 29, 1998·Annual Review of Physiology·M CereijidoR G Contreras
Nov 24, 1999·The Journal of Clinical Investigation·Y Huan, J van Adelsberg
Jul 8, 1998·Proceedings of the National Academy of Sciences of the United States of America·C TselepisD Garrod
Apr 29, 1999·Proceedings of the National Academy of Sciences of the United States of America·A I BarthW J Nelson
Sep 2, 2014·Journal of Ophthalmology·Alla V KuznetsovaMaria A Aleksandrova
Mar 1, 1997·Cell Adhesion and Communication·M S KinchK Burridge
Oct 1, 1995·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·E D Hay, A Zuk
May 29, 2007·Progress in Retinal and Eye Research·Susanne BinderCarl Glittenberg
Jan 5, 2002·Experimental Cell Research·Bin Li, Warren J Gallin
Feb 18, 2006·Biochemical and Biophysical Research Communications·Tsung-Chuan HoYeou-Ping Tsao
May 21, 1999·The American Journal of Medicine·B A Molitoris, J Marrs
Feb 9, 1996·Cell·D G Drubin, W J Nelson
Sep 3, 1999·Mechanisms of Development·K Wertz, B G Herrmann
Aug 26, 2014·Experimental Eye Research·Guillermo L LehmannEnrique Rodriguez-Boulan

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