Plasticity in the Adult: How Should the Waddington Diagram Be Applied to Regenerating Tissues?

Developmental Cell
Jayaraj Rajagopal, Ben Z Stanger

Abstract

Conrad Waddington's eponymous 1957 diagram provided a metaphorical framework for considering how sequential developmental fate decisions allow an egg to develop into an embryo. In recent years, the Waddington diagram has been repurposed to illustrate how cellular identity changes in the context of reprogramming. In this Perspective, we revisit the Waddington diagram in light of the emerging recognition that plasticity is part and parcel of adult regeneration. Specifically, we speculate that the "epigenetic landscapes" that define identity in adult tissues are dynamic, facilitating cellular de-differentiation and trans-differentiation in the setting of injury.

References

May 8, 2002·Nature Reviews. Molecular Cell Biology·David Tosh, Jonathan M W Slack
Jan 31, 2003·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Katia Del Rio-Tsonis, Panagiotis A Tsonis
Jun 23, 2011·Development·Margaret de Cuevas, Erika L Matunis
Mar 23, 2013·Genes & Development·Kilangsungla YangerBen Z Stanger
Oct 16, 2013·Proceedings of the National Academy of Sciences of the United States of America·Tetsuro KusabaBenjamin D Humphreys
Jul 7, 2015·Nature·Ana Pardo-SagantaJayaraj Rajagopal

❮ Previous
Next ❯

Citations

Aug 31, 2016·Communicative & Integrative Biology·Kelly G SullivanMichael Levin
Sep 13, 2016·Diabetes, Obesity & Metabolism·V CigliolaP L Herrera
Nov 29, 2016·Nature Reviews. Nephrology·Monica Chang-Panesso, Benjamin D Humphreys
Apr 21, 2017·Nucleic Acids Research·Andrew P HutchinsDuanqing Pei
Oct 24, 2017·Nature Cell Biology·Michael A ReidJason W Locasale
Nov 15, 2017·Plant & Cell Physiology·Idan Efroni
Oct 5, 2016·Molecular and Cellular Biology·Chinh Q HoangRaymond J MacDonald
Nov 13, 2019·FEBS Letters·Larissa TraxlerJerome Mertens
Oct 12, 2019·Nature Reviews. Drug Discovery·Soufiane Boumahdi, Frederic J de Sauvage
Mar 25, 2019·Stem Cells International·Rosaria SantoroGiulio Pompilio
Jun 30, 2019·Development·Aaron McKenna, James A Gagnon
Jan 29, 2021·Cellular and Molecular Life Sciences : CMLS·Eliya Bitman-Lotan, Amir Orian
Dec 18, 2020·Frontiers in Genetics·Saniya Deshmukh, Supreet Saini
Mar 19, 2021·Frontiers in Cell and Developmental Biology·Luigi Aloia
Jun 8, 2021·EMBO Reports·Aleksandra TataPurushothama Rao Tata
Oct 8, 2021·Biological Reviews of the Cambridge Philosophical Society·Baruch RinkevichBert Hobmayer

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Nature Structural & Molecular Biology
Mo Li, Juan Carlos Izpisua Belmonte
The Journal of Experimental Biology
Denis Noble
Revista de la Facultad de Ciencias Médicas
Aldo R Eynard, Elio A Soria
© 2021 Meta ULC. All rights reserved