Plasticity in the rat prefrontal cortex: linking gene expression and an operant learning with a computational theory.

PloS One
Maximiliano RapanelliBonifacio Silvano Zanutto

Abstract

The plasticity in the medial Prefrontal Cortex (mPFC) of rodents or lateral prefrontal cortex in non human primates (lPFC), plays a key role neural circuits involved in learning and memory. Several genes, like brain-derived neurotrophic factor (BDNF), cAMP response element binding (CREB), Synapsin I, Calcium/calmodulin-dependent protein kinase II (CamKII), activity-regulated cytoskeleton-associated protein (Arc), c-jun and c-fos have been related to plasticity processes. We analysed differential expression of related plasticity genes and immediate early genes in the mPFC of rats during learning an operant conditioning task. Incompletely and completely trained animals were studied because of the distinct events predicted by our computational model at different learning stages. During learning an operant conditioning task, we measured changes in the mRNA levels by Real-Time RT-PCR during learning; expression of these markers associated to plasticity was incremented while learning and such increments began to decline when the task was learned. The plasticity changes in the lPFC during learning predicted by the model matched up with those of the representative gene BDNF. Herein, we showed for the first time that plasticity in the m...Continue Reading

References

Jun 14, 2000·Current Opinion in Neurobiology·T R Soderling
Mar 21, 2002·Proceedings of the National Academy of Sciences of the United States of America·Jeremy R GrayMarcus E Raichle
Oct 18, 2002·Neuron·Wolfram Schultz
Jan 13, 2004·Physiological Reviews·M A Lynch
Oct 16, 2004·Nature·P Read MontagueJonathan D Cohen
Oct 27, 2004·Proceedings of the National Academy of Sciences of the United States of America·Giorgio AicardiMarco Canossa
Feb 18, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Victor Ramírez-AmayaCarol A Barnes
Jul 1, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Wei-Xing PanBrian I Hyland
Jul 22, 2005·Cerebral Cortex·Jean-Claude DreherKaren Faith Berman
Aug 16, 2005·Progress in Neurobiology·Clive R Bramham, Elhoucine Messaoudi
Jul 22, 2006·Biochemical Society Transactions·J SouléC R Bramham
May 29, 2007·PLoS Computational Biology·B Silvano Zanutto, John E R Staddon
Oct 13, 2007·Neurobiology of Learning and Memory·Teiko MiyashitaJohn F Guzowski
Oct 19, 2007·Neurobiology of Learning and Memory·Yuan LuBai Lu
Jun 19, 2008·Annual Review of Neuroscience·Steven W Flavell, Michael E Greenberg
Jul 29, 2008·Nature Neuroscience·Christopher D FiorilloWolfram Schultz
Oct 7, 2008·Current Opinion in Neurobiology·Clive R Bramham
Mar 13, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Steven W Kennerley, Jonathan D Wallis
Jun 9, 2009·Nature Neuroscience·Frédérique KouneiherEtienne Koechlin
Sep 11, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Sanne de WitPaul C Fletcher

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Citations

Dec 3, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Herbert E CovingtonEric J Nestler
Nov 1, 2011·Molecular and Cellular Biochemistry·Kechen BanRosemary A Kozar
Jul 26, 2014·Environmental Toxicology·Lei ShengFashui Hong
Aug 31, 2010·Brain Research Bulletin·Héctor BurgosLuis Constandil
Jun 1, 2010·Brain Research Bulletin·Osvaldo FloresAlejandro Hernández
Mar 8, 2012·The European Journal of Neuroscience·Lisa A BriandR Christopher Pierce
Feb 13, 2010·Journal of Neurochemistry·Maximiliano RapanelliBonifacio Silvano Zanutto
Mar 1, 2016·Neurobiology of Disease·Elizabeth G PittsShannon L Gourley
Sep 30, 2010·IEEE Pulse·M E ValentinuzziR Spelzini
Dec 20, 2011·Brain Research·Nicole Rosskothen-Kuhl, Robert-Benjamin Illing
Dec 11, 2019·Journal of Neuroscience Research·Ellen P WoonShannon L Gourley
Oct 8, 2020·Journal of Neurochemistry·Christina J PerryJee Hyun Kim

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Methods Mentioned

BETA
PCR

Software Mentioned

GraphPad Prism
GraphPad
Primer Express

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