Plasticity of astrocytes of the ventral glial limitans subjacent to the supraoptic nucleus

The Journal of Comparative Neurology
J B Bobak, A K Salm

Abstract

We present evidence of gross morphological changes in astrocytes of the ventral glial limitans (VGL) associated with a well-known model of central nervous system (CNS) plasticity: the hypothalamic supraoptic nucleus (SON). Activity of SON magnocellular neuroendocrine cells (MNCs) was stimulated in experimental rats by substitution of 2% saline for drinking water for 2 or 9 days. Light microscopic measures revealed that a significant decrease in VGL thickness, by 34%, occurred with 9 days of stimulation. Astrocyte nuclei of 9-day dehydrated animals were also found to be 39% closer to the pial surface when compared with controls. Electron microscopy revealed a reorientation of individual astrocytes from a direction perpendicular (vertical) to the pial surface, to one parallel (horizontal) to this region. Vertically oriented astrocytes were found to be greater in the control group, by 49%, when compared with the 9-day dehydrated group, where cells were predominantly horizontal in orientation. Vertically oriented cells were further analyzed as to the direction of their vertical projections. Control, 2-day dehydrated and 9-day rehydrated animals, had more vertical cells which were oriented toward the pial surface when compared with ...Continue Reading

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Citations

Feb 10, 2004·Proceedings of the National Academy of Sciences of the United States of America·Richard PietStéphane H R Oliet
Sep 18, 2009·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Joan Y Summy-Long, Sanmei Hu
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