Plasticity of circadian clocks and consequences for metabolism

Diabetes, Obesity & Metabolism
Claudia P CoomansJ H Meijer

Abstract

The increased prevalence of metabolic disorders and obesity in modern society, together with the widespread use of artificial light at night, have led researchers to investigate whether altered patterns of light exposure contribute to metabolic disorders. This article discusses the experimental evidence that perturbed environmental cycles induce rhythm disorders in the circadian system, thus leading to metabolic disorders. This notion is generally supported by animal studies. Distorted environmental cycles, including continuous exposure to light, affect the neuronal organization of the central circadian pacemaker in the suprachiasmatic nucleus (SCN), its waveform and amplitude of the rhythm in electrical activity. Moreover, repeated exposure to a shifted light cycle or the application of dim light at night are environmental cues that cause a change in SCN function. The effects on the SCN waveform are the result of changes in synchronization among the SCN's neuronal cell population, which lead consistently to metabolic disturbances. Furthermore, we discuss the effects of sleep deprivation and the time of feeding on metabolism, as these factors are associated with exposure to disturbed environmental cycles. Finally, we suggest th...Continue Reading

References

Feb 17, 1998·Neuroscience Letters·R E MistlbergerE G Marchant
Aug 14, 1999·Journal of Neuroendocrinology·S E La FleurR M Buijs
Jan 22, 2000·Journal of Biological Rhythms·A A Borbély, P Achermann
Jan 17, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·D J KennawayR W Moyer
Feb 9, 2002·Science·David M BersonMotoharu Takao
May 7, 2002·Critical Care Medicine·Gerald MundiglerPeter Siostrzonek
Jul 12, 2002·Cell and Tissue Research·Robert Y MooreRehana K Leak
Aug 29, 2002·Nature·Steven M Reppert, David R Weaver
Jul 2, 2003·American Journal of Epidemiology·Yunsheng MaIra S Ockene
Sep 6, 2003·Nature Neuroscience·Tom DeboerJohanna H Meijer
Nov 25, 2003·Science·Shun YamaguchiHitoshi Okamura
Dec 13, 2003·Proceedings of the National Academy of Sciences of the United States of America·Jeroen SchaapJohanna H Meijer
Jun 11, 2004·Liver International : Official Journal of the International Association for the Study of the Liver·Alec J DavidsonFriedrich K Stephan
Mar 5, 2005·Nature Neuroscience·Hidenobu OhtaDouglas G McMahon
Oct 28, 2005·Nature·Clifford B SaperJun Lu
Dec 2, 2005·The Journal of Comparative Neurology·Jeffrey M ZigmanJoel K Elmquist
Oct 31, 2006·American Journal of Epidemiology·Candyce H KroenkeIchiro Kawachi
Nov 7, 2006·Current Biology : CB·A J DavidsonG D Block
Feb 15, 2007·Nature Reviews. Neuroscience·Takeshi Sakurai
Feb 27, 2007·Current Biology : CB·Henk Tjebbe VanderLeestJohanna H Meijer
Jul 25, 2007·Progress in Neurobiology·Timothy M Brown, Hugh D Piggins
Aug 31, 2007·Proceedings of the National Academy of Sciences of the United States of America·Peng Y WoonDominique Gauguier
Dec 12, 2007·International Journal of Obesity : Journal of the International Association for the Study of Obesity·E M ScottP J Grant
Feb 2, 2008·Obesity·Sanjay R Patel, Frank B Hu
Apr 19, 2008·Cold Spring Harbor Symposia on Quantitative Biology·E S MaywoodM H Hastings
May 13, 2008·Neuroscience·R Salgado-DelgadoC Escobar
May 23, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Hee Joo ChoiYang In Kim
Jun 11, 2008·The American Journal of Clinical Nutrition·Silvia SookoianCarlos Jose Pirola
Jun 12, 2008·JAMA : the Journal of the American Medical Association·Rixt F Riemersma-van der LekEus J W Van Someren
Aug 23, 2008·European Journal of Endocrinology·Eve Van Cauter, Kristen L Knutson
Sep 4, 2008·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·D FeskanichE S Schernhammer

❮ Previous
Next ❯

Citations

Nov 8, 2015·Biochimica Et Biophysica Acta·Makoto Ishii, Costantino Iadecola
Jan 17, 2019·Current Nutrition Reports·Tom BaranowskiJennette P Moreno
Mar 17, 2019·EMBO Reports·Samuel Philip NobsEran Elinav
Nov 19, 2019·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·Jennette P MorenoDebbe Thompson
Nov 22, 2019·European Child & Adolescent Psychiatry·Madelon A VollebregtMartijn Arns
Jul 19, 2016·Diabetology International·Navin AdhikaryJia Zhong Sun
Jun 6, 2019·Frontiers in Physiology·Juan Hernández-PérezMarcos A López-Patiño
Mar 9, 2019·The International Journal of Behavioral Nutrition and Physical Activity·Jennette P MorenoTom Baranowski
Jul 28, 2019·Scientific Reports·Daniele SantiManuela Simoni
Oct 19, 2017·Psychiatry Investigation·Paulo Marcos Brasil RochaHumberto Corrêa da Silva Filho
Jul 24, 2021·Scientific Reports·Jari LipsanenAnu-Katriina Pesonen
Nov 2, 2021·American Journal of Physiology. Endocrinology and Metabolism·Xiaojing FanYing Gu

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.