Plasticity of differentiated cells in wound repair and tumorigenesis, part II: skin and intestine

Disease Models & Mechanisms
Joseph Burclaff, Jason C Mills

Abstract

Recent studies have identified and begun to characterize the roles of regenerative cellular plasticity in many organs. In Part I of our two-part Review, we discussed how cells reprogram following injury to the stomach and pancreas. We introduced the concept of a conserved cellular program, much like those governing division and death, which may allow mature cells to become regenerative. This program, paligenosis, is likely necessary to help organs repair the numerous injuries they face over the lifetime of an organism; however, we also postulated that rounds of paligenosis and redifferentiation may allow long-lived cells to accumulate and store oncogenic mutations, and could thereby contribute to tumorigenesis. We have termed the model wherein differentiated cells can store mutations and then unmask them upon cell cycle re-entry the 'cyclical hit' model of tumorigenesis. In the present Review (Part II), we discuss these concepts, and cell plasticity as a whole, in the skin and intestine. Although differentiation and repair are arguably more thoroughly studied in skin and intestine than in stomach and pancreas, it is less clear how mature skin and intestinal cells contribute to tumorigenesis. Moreover, we conclude our Review by ...Continue Reading

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Citations

Apr 4, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Naoki Nanashima, Kayo Horie
Jul 8, 2020·Journal of Cellular and Molecular Medicine·Amandine GuérinSandrine Faure
Jul 25, 2018·Disease Models & Mechanisms·Joseph Burclaff, Jason C Mills
Jul 23, 2019·The Journal of Clinical Investigation·Jennifer C BrazilCharles A Parkos
May 22, 2021·Cellular and Molecular Life Sciences : CMLS·Jose Mario Gonzalez-Meljem, Juan Pedro Martinez-Barbera
Sep 22, 2021·Cellular and Molecular Gastroenterology and Hepatology·Min-Jiao PangZhen-Ning Wang

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Methods Mentioned

BETA
GTPase
biopsy
xenografts

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