Plasticity of histamine H3 receptor expression and binding in the vestibular nuclei after labyrinthectomy in rat

BMC Neuroscience
Adrian F LozadaPertti Panula

Abstract

In rat, deafferentation of one labyrinth (unilateral labyrinthectomy) results in a characteristic syndrome of ocular and motor postural disorders (e.g., barrel rotation, circling behavior, and spontaneous nystagmus). Behavioral recovery (e.g., diminished symptoms), encompassing 1 week after unilateral labyrinthectomy, has been termed vestibular compensation. Evidence suggesting that the histamine H3 receptor plays a key role in vestibular compensation comes from studies indicating that betahistine, a histamine-like drug that acts as both a partial histamine H1 receptor agonist and an H3 receptor antagonist, can accelerate the process of vestibular compensation. Expression levels for histamine H3 receptor (total) as well as three isoforms which display variable lengths of the third intracellular loop of the receptor were analyzed using in situ hybridization on brain sections containing the rat medial vestibular nucleus after unilateral labyrinthectomy. We compared these expression levels to H3 receptor binding densities. Total H3 receptor mRNA levels (detected by oligo probe H3X) as well as mRNA levels of the three receptor isoforms studied (detected by oligo probes H3A, H3B, and H3C) showed a pattern of increase, which was bila...Continue Reading

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Citations

Apr 15, 2006·The Journal of Physiology·Brahim TighiletMichel Lacour
Jul 16, 2008·Physiological Reviews·Helmut L HaasOliver Selbach
Dec 3, 2018·International Journal of Otolaryngology·Augusto Pietro CasaniMichel Lacour
Jun 10, 2010·The Journal of Pharmacology and Experimental Therapeutics·F GbahouJ-M Arrang
Jun 24, 2021·Drugs & Aging·Augusto Pietro CasaniSilvia Capobianco

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