Plasticity of motor network and function in the absence of corticospinal projection

Experimental Neurology
Qi HanLibing Zhou

Abstract

Despite the obvious clinical interest, our understanding of how developmental mechanisms are redeployed during degeneration and regeneration after brain and spinal cord injuries remains quite rudimentary. In animal models of spinal cord injury, although spontaneous regeneration of descending axons is limited, compensation by intact corticospinal axons, descending tracts from the brainstem, and local intrinsic spinal networks all contribute to the recovery of motor function. Here, we investigated spontaneous motor compensation and plasticity that occur in the absence of corticospinal tract, using Celsr3|Emx1 mice in which the corticospinal tract is completely and specifically absent as a consequence of Celsr3 inactivation in the cortex. Mutant mice had no paresis, but displayed hyperactivity in open-field, and a reduction in skilled movements in food pellet manipulation tests. The number of spinal motoneurons was reduced and their terminal arbors at neuromuscular junctions were atrophic, which was reflected in electromyography deficits. Rubrospinal projections, calretinin-positive propriospinal projections, afferent innervation of motoneurons by calretinin-positive segmental interneurons, and terminal ramifications of monoaminer...Continue Reading

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Citations

May 18, 2016·Surgery·Sergio CanaveroEdoardo Rosati
Jun 27, 2017·American Journal of Veterinary Research·Melissa J Lewis, Natasha J Olby
Aug 10, 2018·Frontiers in Neural Circuits·Imran S SheikhGeorge M Smith
Jan 10, 2021·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Benita JinV Reggie Edgerton
Jun 29, 2021·Frontiers in Neuroscience·Rafael Olivares-MorenoGerardo Rojas-Piloni

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