Plasticity of mouse renal collecting duct in response to potassium depletion

Physiological Genomics
L ChevalA Doucet

Abstract

Plasticity of mouse renal collecting duct in response to potassium depletion.--Renal collecting ducts are the main sites for regulation of whole body potassium balance. Changes in dietary intake of potassium induce pleiotropic adaptations of collecting duct cells, which include alterations of ion and water transport properties along with an hypertrophic response. To study the pleiotropic adaptation of the outer medullary collecting duct (OMCD) to dietary potassium depletion, we combined functional studies of renal function (ion, water, and acid/base handling), analysis of OMCD hypertrophy (electron microscopy) and hyperplasia (PCNA labeling), and large scale analysis of gene expression (transcriptome analysis). The transcriptome of OMCD was compared in mice fed either a normal or a potassium-depleted diet for 3 days using serial analysis of gene expression (SAGE) adapted for downsized extracts. SAGE is based on the generation of transcript-specific tag libraries. Approximately 20,000 tags corresponding to 10,000 different molecular species were sequenced in each library. Among the 186 tags differentially expressed (P < 0.05) between the two libraries, 120 were overexpressed and 66 were downregulated. The SAGE expression profile...Continue Reading

Associated Datasets

May 30, 2004·Patrick BrunevalJean-Marc Verbavatz

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Citations

Dec 22, 2004·Pflügers Archiv : European journal of physiology·Olga SoutourinaAlain Doucet
Oct 12, 2012·PloS One·Lydie ChevalAlain Doucet
Jul 25, 2008·Journal of the American Society of Nephrology : JASN·Jean Paul Duong Van HuyenAlain Doucet
Dec 3, 2009·Cellular and Molecular Life Sciences : CMLS·Cheng-Han Huang, Mao Ye
Jul 10, 2010·Current Opinion in Nephrology and Hypertension·Megan M GreenleeCharles S Wingo
Nov 4, 2010·Seminars in Nephrology·Ana VelicCarsten A Wagner
Aug 27, 2016·Pflügers Archiv : European journal of physiology·Christine WalterGilles Crambert
Jun 29, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Daniel AckermannAlain Doucet
Jul 27, 2006·Physiological Genomics·Lydie ChevalAlain Doucet
Apr 6, 2007·American Journal of Physiology. Renal Physiology·Un Sil JeonH Moo Kwon
Aug 2, 2019·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Anne BlanchardGilles Crambert
Nov 18, 2010·Physiological Genomics·Lydie ChevalAlain Doucet
Dec 17, 2019·American Journal of Physiology. Renal Physiology·Hyun-Wook LeeI David Weiner
Jan 26, 2006·American Journal of Physiology. Renal Physiology·Ryan G MorrisMark A Knepper
Aug 10, 2019·Physiological Reports·Alessia SpirliOlivier Staub

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