PMID: 11343290May 9, 2001Paper

Plasticity of neurohypophysial terminals with increased hormonal release during dehydration: ultrastructural and biochemical analyses

The Journal of Comparative Neurology
S MiyataG I Hatton

Abstract

Arginine vasopressin- (AVP) and oxytocin- (OXT) secreting magnocellular neurons undergo gross structural changes with chronic physiological stimulation. Here, we investigated subcellular aspects of plasticity in rat neurohypophysial terminals during dehydration. Ultrastructural analyses demonstrated that chronic dehydration by 2% NaCl drinking for 7 days significantly decreased the numbers of neurosecretory granules and microvesicles but not the numbers of mitochondria. Moreover, in dehydrated rats, terminals making neurovascular contacts enlarged, whereas terminals in apposition to astrocytes, i.e., neuroglial contacts, became smaller. Western blot analyses demonstrated significant decreases in the levels of F3 and Thy-1 together with those of AVP- and OXT-neurophysin, but the levels of synaptophysin, SNAP-25, and GAP-43 were unchanged. Both F3 and Thy-1 were recovered in the buffer-insoluble pellet, and phosphatidyl inositol-specific phospholipase C treatment released both molecules from the crude membrane fraction, indicating that they are attached to terminal membranes by glycosylphosphatidyl inositol anchors. Confocal microscopic observations demonstrated that F3 colocalized with Thy-1 in the same terminals of magnocellula...Continue Reading

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Citations

Dec 31, 2010·Cell and Tissue Research·Yuki TaniguchiSeiji Miyata
Jun 1, 2005·Molecular and Cellular Neurosciences·Stéphanie MonlezunDionysia T Theodosis
Mar 10, 2004·Neurobiology of Disease·Joshua P KleinStephen G Waxman
Feb 23, 2011·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Ouahiba Mesbah-BenmessaoudValérie Grange-Messent
Jan 25, 2006·Proceedings of the National Academy of Sciences of the United States of America·Charles HindmarchDavid Murphy
Aug 17, 2005·The European Journal of Neuroscience·Akiko KawasakiSetsuji Hisano
Aug 28, 2009·Cell Biochemistry and Function·Takashi HashimotoSeiji Miyata
May 19, 2004·The European Journal of Neuroscience·Vicky A TobinMike Ludwig
Jul 8, 2008·Journal of Neuroendocrinology·E Hrabovszky, Z Liposits
Nov 2, 2006·Journal of Neuroendocrinology·J Y Summy-LongT M Phillips
Mar 26, 2013·Journal of Neuroscience Research·Atsushi Hourai, Seiji Miyata
Feb 1, 2005·Brain Research·Yu-Feng Wang, Glenn I Hatton
Oct 9, 2012·Neuron·Anthony N van den Pol
Dec 19, 2013·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·C C T HindmarchD Murphy
Jan 26, 2002·Microscopy Research and Technique·Seiji Miyata, Glenn I Hatton
Jun 11, 2019·ELife·Savani AnbalaganGil Levkowitz
May 15, 2020·Journal of Neuroendocrinology·Colin H BrownJavier E Stern
Nov 22, 2002·Advances in Physiology Education·Glenn I Hatton

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