Plasticity of PDZ domains in ligand recognition and signaling.

FEBS Letters
Ylva Ivarsson

Abstract

The PDZ domain is a protein-protein interacting module that plays an important role in the organization of signaling complexes. The recognition of short intrinsically disordered C-terminal peptide motifs is the archetypical PDZ function, but the functional repertoire of this versatile module also includes recognition of internal peptide sequences, dimerization and phospholipid binding. The PDZ function can be tuned by various means such as allosteric effects, changes of physiological buffer conditions and phosphorylation of PDZ domains and/or ligands, which poses PDZ domains as dynamic regulators of cell signaling. This review is focused on the plasticity of the PDZ interactions.

References

Aug 15, 1996·Nature·J H Morais CabralR C Liddington
Feb 1, 1997·Protein Science : a Publication of the Protein Society·C P Ponting
Jun 24, 1997·Proceedings of the National Academy of Sciences of the United States of America·S S LeeR T Javier
Oct 23, 1997·Proceedings of the National Academy of Sciences of the United States of America·T KiyonoM Ishibashi
Aug 15, 1998·The Journal of Biological Chemistry·S H GeeB K Kay
Jan 28, 1999·The Journal of Biological Chemistry·D LinT Pawson
Jun 25, 2002·Nature Structural Biology·Jose ReinaCayetano Gonzalez
Jun 28, 2002·Molecular Cell·Pascale ZimmermannJan Gettemans
Nov 19, 2002·FEBS Letters·Jodene EldstromDavid Fedida
Nov 22, 2002·The Journal of Biological Chemistry·Gabriel BirraneJohn A A Ladias
Mar 12, 2003·Biochemistry·Baruch Z HarrisWendell A Lim
Aug 23, 2003·The Journal of Biological Chemistry·Fabrizio GardoniMonica Di Luca
Mar 17, 2004·Molecular Cell·Francis C PetersonKenneth E Prehoda
Jun 23, 2004·Molecular and Cellular Neurosciences·Takeshi UemuraMasayoshi Mishina
Aug 18, 2004·Biochemical and Biophysical Research Communications·Timothy B C LondonJie Zheng
Oct 12, 2004·Nature Structural & Molecular Biology·Rhiannon R PenkertKenneth E Prehoda
Dec 2, 2004·Brain Research. Brain Research Reviews·Jimena Sierralta, Carolina Mendoza
Jun 18, 2005·The EMBO Journal·Eva MortierPascale Zimmermann
Jul 12, 2005·Nature Structural & Molecular Biology·Jia-Fu LongMingjie Zhang
Sep 6, 2005·Developmental Cell·Pascale ZimmermannGuido David

❮ Previous
Next ❯

Citations

Feb 26, 2014·BMC Genomics·Kousik Kundu, Rolf Backofen
Mar 4, 2014·Protein Engineering, Design & Selection : PEDS·Qian ChaiYinan Wei
Mar 13, 2014·Human Molecular Genetics·Katharina BaußUwe Wolfrum
May 13, 2014·Journal of Molecular Biology·Javier Murciano-CallesSachdev S Sidhu
Jul 9, 2013·Acta Crystallographica. Section F, Structural Biology and Crystallization Communications·Huijong Han, Petri Kursula
Aug 25, 2015·Cell Communication and Signaling : CCS·Cecilia Blikstad, Ylva Ivarsson
Nov 22, 2015·Cell Communication and Signaling : CCS·Norman E DaveyAlan M Moses
Mar 27, 2015·Neoplasia : an International Journal for Oncology Research·Jenny G ParvaniWilliam P Schiemann
May 28, 2013·Journal of the American Chemical Society·Jonas N N EildalPer Jemth
Mar 5, 2016·Protein Engineering, Design & Selection : PEDS·Angelo TotoPer Jemth
Feb 15, 2015·Virus Research·Flavia Leite, Michael Way
Mar 24, 2015·Scientific Reports·O Andreas KarlssonPer Jemth
Jun 8, 2012·BioFactors·Celestine N ChiPer Jemth
Aug 27, 2014·Journal of Molecular Biology·Andreas ErnstSachdev S Sidhu
Jul 3, 2015·The Journal of Chemical Physics·Marcos GrossoSebastian Fernandez-Alberti
Oct 9, 2014·BioMed Research International·Gustav N Sundell, Ylva Ivarsson
Jan 27, 2015·Biochemical Society Transactions·Matthew Gallon, Peter J Cullen
Apr 22, 2014·Biophysical Chemistry·Stefano GianniPer Jemth
Apr 16, 2013·Journal of Molecular Biology·Shibani BhattacharyaZimei Bu
Jun 19, 2013·Cellular Signalling·Geng-Xian ShiDouglas A Andres
Nov 20, 2012·Structure·Colin A SmithTanja Kortemme
Jan 28, 2015·The International Journal of Biochemistry & Cell Biology·Ran YanKatherine J D A Excoffon
Jul 9, 2016·Nature Communications·Antonio Luis Egea-JimenezPascale Zimmermann
Mar 14, 2013·Journal of the American Chemical Society·Matthieu SainlosBarbara Imperiali
Oct 21, 2016·Protein Engineering, Design & Selection : PEDS·Angelo TotoStefano Gianni
Oct 30, 2016·American Journal of Physiology. Lung Cellular and Molecular Physiology·Neeraj SharmaGarry R Cutting
Feb 24, 2018·Journal of Neurochemistry·Srinivas Kumar PonnaPetri Kursula
Sep 11, 2018·Acta Crystallographica. Section D, Structural Biology·Khundrakpam Herojit SinghBichitra Kumar Biswal
Aug 22, 2018·Molecular Systems Biology·Gustav N SundellYlva Ivarsson
Apr 2, 2020·The Journal of Immunology : Official Journal of the American Association of Immunologists·Anne-Laure BaillyMichel Aurrand-Lions
Feb 3, 2016·The Biochemical Journal·Elisabeth DarrouzetThierry Pourcher
Sep 22, 2019·Nature Communications·Aurelia StanglDaniel Krappmann

❮ Previous
Next ❯

Methods Mentioned

BETA
phage display
NMR
GTPase
gel filtration

Related Concepts

Related Feeds

Alternative splicing

Alternative splicing a regulated gene expression process that allows a single genetic sequence to code for multiple proteins. Here is that latest research.

© 2021 Meta ULC. All rights reserved