Plasticity of tumour and immune cells: a source of heterogeneity and a cause for therapy resistance?

Nature Reviews. Cancer
Michael HölzelThomas Tüting

Abstract

Immunotherapies, signal transduction inhibitors and chemotherapies can successfully achieve remissions in advanced stage cancer patients, but durable responses are rare. Using malignant melanoma as a paradigm, we propose that therapy-induced injury to tumour tissue and the resultant inflammation can activate protective and regenerative responses that represent a shared resistance mechanism to different treatments. Inflammation-driven phenotypic plasticity alters the antigenic landscape of tumour cells, rewires oncogenic signalling networks, protects against cell death and reprogrammes immune cell functions. We propose that the successful combination of cancer treatments to tackle resistance requires an interdisciplinary understanding of these resistance mechanisms, supported by mathematical models.

References

Jan 17, 1996·Journal of the National Cancer Institute·N P RestifoS A Rosenberg
Jun 11, 1996·Proceedings of the National Academy of Sciences of the United States of America·H TakayamaG Merlino
Jan 21, 1997·Proceedings of the National Academy of Sciences of the United States of America·H TakayamaG Merlino
Apr 10, 1997·International Journal of Cancer. Journal International Du Cancer·E JägerA Knuth
Dec 9, 1998·Proceedings of the National Academy of Sciences of the United States of America·M B EisenD Botstein
Nov 24, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·M B AtkinsS A Rosenberg
Apr 5, 2001·The New England Journal of Medicine·B J DrukerC L Sawyers
Mar 21, 2002·Nature Reviews. Cancer·Michael M GottesmanSusan E Bates
Oct 31, 2002·Nature Immunology·Hung T Khong, Nicholas P Restifo
Jun 6, 2003·Oncogene·Mary J C HendrixRichard E B Seftor
Feb 19, 2004·Proceedings of the National Academy of Sciences of the United States of America·Tian-Li WangVictor E Velculescu
Jul 13, 2004·Science·Joseph N Blattman, Philip D Greenberg
Sep 2, 2004·Nature Medicine·Steven A RosenbergNicholas P Restifo
Sep 3, 2004·The New England Journal of Medicine·Hensin TsaoArthur J Sober
Jan 5, 2005·Nature Reviews. Cancer·Bruce A Chabner, Thomas G Roberts
Feb 25, 2005·The New England Journal of Medicine·Susumu KobayashiBalázs Halmos
Apr 1, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Mark E DudleySteven A Rosenberg
Oct 21, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Steven A RosenbergSeth M Steinberg
Mar 23, 2006·Annual Review of Immunology·Thierry BoonPierre van der Bruggen
Jul 20, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Keith L KnutsonMary L Disis
Jul 20, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Victor AppayDaniel E Speiser
Aug 30, 2006·Proceedings of the National Academy of Sciences of the United States of America·Robert AxelrodKenneth J Pienta
Nov 1, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Andreas MackensenReinhard Andreesen
Nov 17, 2006·Nature Reviews. Cancer·Lauren M F MerloCarlo C Maley
Dec 1, 2006·Annual Review of Immunology·Gabriel A RabinovichEduardo M Sotomayor
Jan 11, 2007·Cancer Research·Vanessa C Gray-SchopferRichard Marais
Dec 8, 2007·Nature Reviews. Immunology·Andrew L Mellor, David H Munn
Feb 5, 2008·Cancer Research·Keith S HoekReinhard Dummer
Mar 26, 2008·Nature Genetics·Murat AcarAlexander van Oudenaarden
Sep 13, 2008·Cell Stem Cell·Richard Mark White, Leonard I Zon
Nov 29, 2008·Science·Charles G MullighanJames R Downing
Mar 12, 2009·Cancer Research·Marta SantistebanKeith L Knutson
May 27, 2009·Carcinogenesis·Francesco ColottaAlberto Mantovani
Jul 15, 2009·Seminars in Cell & Developmental Biology·Sui HuangStuart Kauffman

❮ Previous
Next ❯

Citations

May 28, 2013·Cancer Metastasis Reviews·Asfar S AzmiFazlul H Sarkar
Dec 11, 2013·The Journal of Experimental Medicine·Fiorenza LottiJeremy N Rich
Jan 8, 2014·Acta Biochimica Et Biophysica Sinica·Xin Huang, Jianhong Zuo
Jul 7, 2014·Journal of Mammary Gland Biology and Neoplasia·Sarah T Boyle, Marina Kochetkova
Jul 11, 2014·Current Opinion in Pharmacology·Joost P J J Hegmans, Joachim G J V Aerts
Sep 24, 2014·Proceedings of the National Academy of Sciences of the United States of America·Mingyang LuEshel Ben-Jacob
Jan 24, 2016·The Journal of Investigative Dermatology·Jennifer LandsbergClaire Lugassy
Mar 5, 2016·Oncoimmunology·Stefanie Andrea Erika HeldPeter Brossart
May 28, 2014·Neoplasia : an International Journal for Oncology Research·Robert TorkaAxel Ullrich
Mar 2, 2016·Proceedings of the National Academy of Sciences of the United States of America·Qin LiIngemar Ernberg
Jan 4, 2015·Nanomedicine : Nanotechnology, Biology, and Medicine·Jun LiJuan Tao
Apr 16, 2014·The Journal of Investigative Dermatology·Reinhard DummerMitchell P Levesque
Jan 16, 2014·The Journal of Investigative Dermatology·Peter GeserickMartin Leverkus
Oct 7, 2015·Trends in Immunology·Mary Philip, Andrea Schietinger
May 30, 2015·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Laurine VersetPieter Demetter
May 9, 2014·Pigment Cell & Melanoma Research·Emanuela BastoniniColin R Goding
Feb 8, 2014·ChemMedChem·Miles A MillerRalph Weissleder
Oct 12, 2013·British Journal of Haematology·Roman HajekHana Svachova
Apr 7, 2016·Biomicrofluidics·N de LangeA R Abate
Apr 22, 2014·Translational Research : the Journal of Laboratory and Clinical Medicine·Julia IllánDolores Subirá
Apr 12, 2016·Scientific Reports·Martina BaarAnton Bovier
Aug 11, 2015·Frontiers in Immunology·Matías Sáenz-CuestaDavid Otaegui
May 7, 2016·Trends in Immunology·Michael Hölzel, Thomas Tüting
Apr 18, 2014·Journal of Immunology Research·Massimo PancioneVittorio Colantuoni
May 7, 2014·Oncoimmunology·Erika VacchelliLorenzo Galluzzi
Oct 30, 2013·Oncoimmunology·Joost Pjj Hegmans, Joachim Gjv Aerts
Jan 30, 2015·Frontiers in Immunology·Joana Carvalho, Carla Oliveira
Jul 2, 2016·Cell·M Angela NietoJean Paul Thiery
Jul 15, 2016·Virchows Archiv : an International Journal of Pathology·Giorgio StantaGerald Hoefler
Sep 27, 2016·The Breast : Official Journal of the European Society of Mastology·Kobra VelaeiJafar Soleimani Rad
Aug 13, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·C Norman ColemanDavid G Kirsch
Dec 3, 2016·Scientific Reports·Gizem Calibasi KocalUtkan Demirci
Jul 26, 2017·Nature Reviews. Cancer·Timothy A YapDean A Fennell
Feb 22, 2018·International Journal of Molecular Sciences·Marcella Regina CardosoSophie Françoise Mauricette Derchain
Dec 12, 2017·Frontiers in Immunology·Stéphane TerrySalem Chouaib
Jan 31, 2018·BioMed Research International·Shuai WangYu Ling Sun

❮ Previous
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