Plasticity Region Genes jhp0940, jhp0945, jhp0947, and jhp0949 of Helicobacter pylori in Isolates from Mexican Children

Helicobacter
Carolina Romo-GonzálezRafael Coria-Jiménez

Abstract

The genes jhp0940, jhp0945, jhp0947, and jhp0949 belong to the plasticity region of the Helicobacter pylori genome. Due to their prevalence in isolates from patients with gastritis, duodenal ulcer, and gastric cancer, they have been proposed as markers of gastroduodenal diseases. These genes are associated with pro-inflammatory cytokine induction through the NF-κB activation pathway. Nevertheless, the status of these genes is unknown in H. pylori isolates from children. The aim of the present work was to determine the frequency of the jhp0940-jhp0945-jhp0947-jhp0949 genes in H. pylori isolates from children. We identified the jhp0940, jhp0945, jhp0947, and jhp0949 genes and the relationship of each with the virulence factors cagA, cagPAI, and dupA by PCR in 49 isolates of H. pylori from children. The results were corroborated using dot blots. In addition, we compared the prevalence of these genes with the prevalence in adults. The prevalence of jhp0940 (53.1%), jhp0945 (44.9%), jhp0947 (77.6%), and jhp0949 (83.7%) was determined in the isolates from children, as was the prevalence of the virulence genes cagA (63.3%), cagPAI (71.4%), and dupA (37.5%). No association was found between the four genes of the plasticity region and t...Continue Reading

References

Aug 1, 1996·Scandinavian Journal of Gastroenterology·W Z LiuZ J Pang
May 21, 1998·Molecular Microbiology·N S AkopyantsD E Berg
Dec 20, 2000·Proceedings of the National Academy of Sciences of the United States of America·N SalamaS Falkow
Nov 14, 2001·Infection and Immunity·B BjörkholmL Engstrand
Nov 29, 2001·Proceedings of the National Academy of Sciences of the United States of America·D A IsraelR M Peek
Apr 19, 2003·Journal of Clinical Microbiology·Adriana SantosFrancis Mégraud
Jun 5, 2003·Cellular Microbiology·Jiro TanakaChihiro Sasakawa
Apr 13, 2005·Gastroenterology·Hong LuYoshio Yamaoka
Oct 12, 2005·PLoS Genetics·Helga GressmannMark Achtman
Apr 17, 2007·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Barik A SalihNiyaz Ahmed
Jun 15, 2007·Nature Cell Biology·Joseph D MougousJohn J Mekalanos
Sep 28, 2007·International Journal of Medical Microbiology : IJMM·Luciana I GomesDulciene M M Queiroz
Oct 6, 2007·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Richard H ArgentJohn C Atherton
Apr 17, 2008·International Journal of Cancer. Journal International Du Cancer·Masami SuganumaHirota Fujiki
Apr 26, 2008·Journal of Medical Microbiology·Yoshio Yamaoka
Apr 26, 2008·Journal of Medical Microbiology·Masoumeh DouraghiNazanin Mohajerani
Sep 4, 2009·PloS One·Dangeruta KersulyteDouglas E Berg
Sep 29, 2009·International Journal of Medical Microbiology : IJMM·Knut Ohlsen, Stefanie Donat
Nov 26, 2010·Proceedings of the National Academy of Sciences of the United States of America·Do Jin KimSe Won Suh
Nov 26, 2011·Journal of Clinical Microbiology·Mitsushige SugimotoYoshio Yamaoka
Jan 25, 2014·The Journal of Venomous Animals and Toxins Including Tropical Diseases·Weendelly Nayara PereiraLucas Trevizani Rasmussen

❮ Previous
Next ❯

Citations

Aug 18, 2016·Helicobacter·Andrea SustmannSibylle Koletzko
Aug 18, 2016·Helicobacter·Elvire BerthenetFilipa F Vale
Aug 6, 2020·Frontiers in Microbiology·Wolfgang FischerSteffen Backert
Sep 24, 2019·World Journal of Gastroenterology : WJG·Anja ŠterbencMatjaž Homan

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atrophic Gastritis

Atrophic Gastritis is a process where gastric glandular cells are lost and replaced with firbous tissues, as a result of chronic inflammation. Learn more about Atrophic Gastritis here.