PMID: 37293May 1, 1979

Plasticization of cellulose ethers used in the film coating of tablets

The Journal of Pharmacy and Pharmacology
C A Entwistle, R C Rowe

Abstract

Plasticizer/polymer interactions have been studied by measuring the intrinsic viscosities of both ethyl cellulose and hydroxypropyl methylcellulose in a series of dialkyl phthalates and in a series of liquid glycols respectively. A correlation was found between the intrinsic viscosity of the polymer/plasticizer solutions and the tensile strength, elongation at rupture and work done in stressing to failure of cast films--the mechanical properties being at a minimum when the intrinsic viscosity was at a maximum. This correlation held only within a homologous series of plasticizers and none was found for plasticizers of different structures. A relationship was found between the lowering of a calculated glass transition temperature of hydroxypropyl methylcellulose in the presence of the plasticizers propylene glycol, polyethylene glycol 200 and glycerol and the intrinsic viscosity of the corresponding solutions--the higher the viscosity the greater the lowering of the transition temperature.

References

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Citations

Jan 1, 1950·Proceedings of the National Academy of Sciences of the United States of America·J H Hildebrand

Related Concepts

Polyethylene Glycol 200
Muscle Tensile Strength
Drug Formulation Process
Glycerin
Ethers for general anesthesia
Ethers
Phthalates
Hypromellose
Plasticizers
Viscosity

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