PMID: 9186805Jun 1, 1997Paper

Platelet [3H]imipramine and [3H]paroxetine binding in depressed patients

Journal of Affective Disorders
P RoselP Alvarez

Abstract

[3H]Paroxetine and [3H]imipramine binding to blood platelet membranes was simultaneously measured in 63 control subjects and 18 patients with DSM-III-R criteria for major depression with melancholia. Both binding sites showed significantly different (p < 0.001) maximum binding (Bmax) and equilibrium dissociation constant (Kd) values. Age was not correlated with either [3H]imipramine Bmax or Kd values, but a negative correlation was found between [3H]paroxetine Bmax and age in healthy controls. Furthermore, depressed patients showed significantly lower [3H]imipramine Bmax values (p < 0.001) and higher Kd values (p < 0.001) in comparison to the control group. No differences were observed in [3H]paroxetine Bmax and Kd values between the two groups.

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Citations

Jan 1, 1997·Journal of Neural Transmission·P RoselM A Navarro
Sep 6, 2003·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Marion KretzschmarBernd Johannsen
Jul 17, 1998·Journal of the American Academy of Child and Adolescent Psychiatry·F R SalleeL Nesbitt
Dec 22, 2005·The Journal of Medical Investigation : JMI·Tetsuro OhmoriKazuhito Rokutan
May 20, 2008·Annals of Medicine·Jun-ichi IgaTetsuro Ohmori
Sep 26, 2003·Psychosomatic Medicine·Annique SchinsKarly Hamulyák

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