PMID: 6697475Jan 1, 1984Paper

Platelet-activating factor: a possible mediator of the dual response to allergen?

Clinical Allergy
G S BasranJ Morley

Abstract

Certain allergic asthmatic patients exhibit a dual response in the lung following bronchial challenge with the appropriate allergen. Often this is paralleled by a cutaneous dual response when the antigen is injected intradermally. The mechanisms underlying such phenomena are not established, but some evidence suggests that the late response is a consequence of the early response. Since platelet activation has been observed following antigen challenge in asthmatic subjects, we have studied the ability of platelet activating factor (PAF-acether, AGEPC) to induce cutaneous inflammatory responses in man. In a time course study over 24 hr, PAF-acether produced a biphasic response: an immediate weal and flare reaction, which resolved within 1-2 hr and was followed some 3-6 hr later by a delayed reaction in which erythema associated with hyperalgesia was evident. These observations suggest that PAF-acether should be considered in the context of allergic asthma as a possible mediator of the dual response to allergen.

References

Aug 1, 1976·The Journal of Clinical Investigation·G O SolleyA L Schroeter
Feb 1, 1976·The Journal of Allergy and Clinical Immunology·J PoothullilR P Day
Oct 1, 1974·The Journal of Allergy and Clinical Immunology·D G RobertsonJ Dolovich
Jul 1, 1973·The Journal of Allergy and Clinical Immunology·J DolovichJ Bienenstock
Jan 1, 1981·Annals of the New York Academy of Sciences·B B VargaftigF Wal
Jun 4, 1981·The New England Journal of Medicine·K A KnauerJ E Fish
Feb 1, 1981·The Journal of Allergy and Clinical Immunology·W Dorsch, J Ring

Citations

Jan 1, 1984·European Journal of Clinical Pharmacology·G Karlsson, U Pipkorn
Jan 1, 1988·Journal of Clinical Immunology·R F Lemanske, M Kaliner
Oct 1, 1986·Agents and Actions·J Morley
Jan 1, 1986·Agents and Actions·J P TarayreJ Tisne-Versailles
Jun 15, 1984·European Journal of Pharmacology·D V McGivern, G S Basran
Jun 10, 1988·European Journal of Pharmacology·J LefortB B Vargaftig
Feb 1, 1988·The Journal of Allergy and Clinical Immunology·A B BeckerW M Gold
Nov 17, 1984·Lancet·J MorleyC P Page
Feb 7, 2001·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·M B Lierl
Dec 3, 1999·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·S L Spector
Nov 1, 1993·Clinical and Experimental Dermatology·C B Archer
Jan 1, 1990·Fundamental & Clinical Pharmacology·P DevillierJ Benveniste
Aug 2, 2011·Biological & Pharmaceutical Bulletin·Makoto TsudaKazuhide Inoue
Jul 1, 1990·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·G Thomas, M K Church
Jul 1, 1990·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·P MaestrelliL M Fabbri
Dec 1, 1994·The Journal of Allergy and Clinical Immunology·E N Charlesworth
Mar 1, 1985·Clinical Allergy·R Grönneberg, O Zetterström
Aug 1, 1987·Acta Neurologica Scandinavica·A R CananziG D'Andrea
Dec 11, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ronan LordanConstantinos A Demopoulos
Oct 1, 1985·Journal of the Royal Society of Medicine·C J Spry
Apr 9, 2021·The Journal of Allergy and Clinical Immunology·Pierre Bruhns, Sylvie Chollet-Martin
May 1, 1989·Biochemical Pharmacology·M PretolaniB B Vargaftig
Aug 21, 1986·Biochimica Et Biophysica Acta·P Bette-BobilloA Bienvenue

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