Platelet-activating factor acether (PAF-acether) involvement in acute inflammatory and pain processes

Agents and Actions
J BonnetP Bessin

Abstract

PAF-acether is a potent aggregating agent released by various cells involved in acute inflammatory process. In this paper, exogenous PAF-acether has been investigated for its ability to generate signs of inflammation (edema measured by plethysmometry) and hyperalgesia (Randall-Sellito test) by standard subplantar injection in the rat paw. From 0.005 microgram. PAF-acether induced significant edema of the paw, maximal 1 hour after injection; it was dose-dependent from 0.1 to 5 microgram. Significant dose-dependent hyperalgesia occurred from 1.25 microgram; it reached a plateau from 2 to 4 hours after injection. Both phenomena were long-lasting (greater than 6 h). PAF-acether was 1.5 to 10 times stronger than PGI2 and PGE2 in inducing edema, pain, and in increasing vascular permeability. We investigated the interaction of miscellaneous drugs with the edema and the hyperalgesia caused by 2.5 microgram of PAF-acether. Non-steroidal anti-inflammatory (NSAI) drugs exerted only moderate effects on the edema without affecting hyperalgesia. Edema was highly reduced by various agents: prednisolone, L-cysteine, anti-calcic drugs, theophylline, PGI2, salbutamol, clonidine. All of them, except clonidine, and in contrast to NSAI drugs, were ...Continue Reading

References

Dec 1, 1986·Inflammation·P S SilvaB B Vargaftig
Jun 1, 1986·Agents and Actions·K F Swingle, M J Reiter
Dec 1, 1981·Agents and Actions·J Benveniste
Jan 1, 1986·Agents and Actions·J P TarayreJ Tisne-Versailles
Nov 29, 2012·Naunyn-Schmiedeberg's Archives of Pharmacology·Ana T GuerreroThiago M Cunha
Jan 21, 1983·European Journal of Pharmacology·P BessinJ Benveniste
Dec 9, 1983·European Journal of Pharmacology·J Björk, G Smedegård
Apr 29, 1987·European Journal of Pharmacology·M A MartinsB B Vargaftig
Jun 20, 1989·European Journal of Pharmacology·J S FranzoneP Biffignandi
Aug 22, 1994·European Journal of Pharmacology·G EmanuelliG Camussi
Jan 1, 1995·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·A CarusoM Amico-Roxas
Jul 10, 1999·Toxicon : Official Journal of the International Society on Toxinology·S A AliD Shehnaz
Feb 13, 1982·Lancet·E PirotzkyC Noirot
Dec 1, 1994·Journal of Veterinary Pharmacology and Therapeutics·P C MillsD E Auer
Mar 1, 1990·The Journal of Pharmacy and Pharmacology·H C Castro-Faria-NetoB B Vargaftig
Jul 1, 1986·Annals of the Rheumatic Diseases·T WoodruffJ Lunec
Aug 2, 2011·Biological & Pharmaceutical Bulletin·Makoto TsudaKazuhide Inoue
Jan 1, 1988·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·T KobayashiS Tanayama
Nov 1, 1985·Journal of Endodontics·S Seltzer, I J Naidorf
Jul 23, 2003·British Journal of Pharmacology·Joice Maria CunhaFernando Queiroz Cunha
Dec 1, 1987·Pharmacological Research Communications·J P TarayreJ P Couzinier
Jan 1, 1989·Pulmonary Pharmacology·D SpinaC P Page
Oct 1, 1987·The Journal of Pharmacy and Pharmacology·P D GautheronM F Sugrue
Jul 1, 1985·The British Journal of Dermatology·E PirotzkyJ Benveniste
Jan 1, 1981·Annals of the New York Academy of Sciences·B B VargaftigF Wal
Apr 1, 1985·British Journal of Pharmacology·A DetsouliB B Vargaftig
Sep 1, 1984·British Journal of Pharmacology·A M LeferJ B Smith
Mar 1, 1983·British Journal of Haematology·C L KeralyJ Benveniste
Jun 1, 1983·British Journal of Pharmacology·A MyersP Ramwell

Citations

Sep 1, 1976·Nihon yakurigaku zasshi. Folia pharmacologica Japonica·S Masumoto, C Masuda
Mar 1, 1977·Prostaglandins·R R GormanO V Miller
Apr 1, 1977·Prostaglandins·S MoncadaP Needleman
Apr 30, 1971·Annals of the New York Academy of Sciences·G Kaley, R Weiner

Related Concepts

Arterial Pulse Pressure
Exertion
Mucositis
Anti-Inflammatory Agents
Analgesics
Cyclic AMP
Prednisolone
Vascular Permeability
Etiology
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