Platelet-activating factor acetylhydrolase is not associated with carotid intima-media thickness in hypercholesterolemic Sicilian individuals

Clinical Chemistry
Salvatore CampoAntonino Saitta

Abstract

Atherosclerosis is a complex, chronic disease that usually arises from the converging action of several pathogenic processes, including hypertension, hyperlipidemia, obesity, and the accumulation of oxidized LDL. Platelet-activating factor acetylhydrolase (PAF-AH) is a LDL- and HDL-bound enzyme that hydrolyzes and inactivates PAF and prevents LDL-cholesterol oxidation, thus delaying the onset of atherosclerotic disease. We evaluated the relationship between variants of the PAF-AH gene polymorphisms Arg92His, Ile198Thr, and Ala379Val and the presence of carotid atherosclerosis in 190 hypercholesterolemic Sicilian individuals. Carotid artery intima-media wall thickness (IMT) was measured as an indicator of early atherosclerotic disease. The participants were classified according to having normal (< or =1 mm) or abnormal (> or =1 mm) IMT and were also investigated for physical characteristics and biochemical indices, including PAF-AH activity. PAF-AH activity and LDL concentrations were significantly correlated in hypercholesterolemic patients, but plasma PAF-AH activity and HDL were not significantly correlated in either IMT group. No significant differences were detected among the PAF-AH gene polymorphisms in both groups after c...Continue Reading

References

Aug 1, 1992·Stroke; a Journal of Cerebral Circulation·K SatohS Mizuno
Nov 1, 1991·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·J L WoffordJ R Crouse
May 1, 1994·European Journal of Vascular Surgery·M R de Groot, J D Banga
Jun 11, 1996·Biochimica Et Biophysica Acta·D M StafforiniT M McIntyre
Jul 30, 1997·Biochemical and Biophysical Research Communications·Y Yamada, M Yokota
Jan 22, 1998·Biochemical and Biophysical Research Communications·R BellI S Gloger
May 16, 2000·Clinica Chimica Acta; International Journal of Clinical Chemistry·T KosakaK Mizuno
Aug 18, 2000·Free Radical Biology & Medicine·G M Chisolm, D Steinberg
Feb 12, 2002·Lipids·F Visioli, C Galli
Jan 28, 2003·Progress in Lipid Research·Ken KarasawaMorio Setaka
May 13, 2003·Journal of Atherosclerosis and Thrombosis·Jianglin Fan, Teruo Watanabe
Jul 18, 2003·Journal of Lipid Research·Anna I KakafikaAlexandros D Tselepis
Sep 25, 2003·Physiological Reviews·Bjarne Osterud, Eirik Bjorklid

❮ Previous
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Citations

Oct 1, 2011·Lipids in Health and Disease·Isis T SilvaNágila R T Damasceno
Aug 12, 2006·Current Atherosclerosis Reports·Vijay Nambi, Christie M Ballantyne
Apr 28, 2006·Current Atherosclerosis Reports·Rebecca L Pollex, Robert Hegele
Mar 9, 2006·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·Paul M WalshLiam Murray
Oct 31, 2006·Journal of Diabetes and Its Complications·Hiroshi NotoPhilip Raskin
Nov 16, 2007·International Journal of Immunogenetics·M Gomez LiraP F Pignatti
Jun 11, 2008·Journal of Neuroscience Research·Peter GassPeter J Gebicke-Haerter
Nov 9, 2010·Journal of Internal Medicine·K C Epps, R L Wilensky
Oct 20, 2006·Biochimica Et Biophysica Acta·Ken Karasawa
Jun 30, 2006·Biochimica Et Biophysica Acta·Sonia-Athina Karabina, Ewa Ninio
Oct 28, 2015·BioMed Research International·Anna SödergrenSolveig Wållberg-Jonsson
Feb 16, 2007·European Journal of Cardiovascular Prevention and Rehabilitation : Official Journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology·UNKNOWN Lp-PLA2 Studies CollaborationA Wood
Dec 24, 2005·Arteriosclerosis, Thrombosis, and Vascular Biology·Isabella KardysJacqueline C M Witteman
Sep 19, 2009·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Yoshikazu MiwaYuhei Kawano
Feb 29, 2020·Genetic Testing and Molecular Biomarkers·Changzhu WuWensheng Han
Aug 21, 2007·Molecular Diagnosis & Therapy·Natalie Khuseyinova, Wolfgang Koenig

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