Platelet-activating factor and cerebral vasospasm following subarachnoid hemorrhage

Journal of Neurosurgery
Y HirashimaA Takaku

Abstract

This study examines whether platelet-activating factor (PAF) is involved in the occurrence of vasospasm after subarachnoid hemorrhage (SAH). A vasospasm model was produced in rabbits, with animals in six experimental groups receiving two subarachnoid injections of autologous arterial blood with the addition of one of the following; saline (Control Group 1), 25% dimethyl sulfoxide (Control Group 2), PAF (1, 2.5, 5, or 10 micrograms), CV6209 (10 or 100 micrograms), BN52021 (10 or 100 micrograms), or anti-PAF immunoglobulin G (IgG, 50 or 500 micrograms). No significant differences were detected between Control Groups 1 and 2 with regard to neurological deterioration and basilar artery constriction after SAH was induced. Administration of PAF together with autologous blood aggravated neurological deficits in a dose-dependent manner (r = 0.724, p < 0.001) and produced basilar artery constriction at two doses each of 2.5 micrograms (p < 0.05), 5 micrograms (p < 0.01), and 10 micrograms (p < 0.01). Neurological deterioration was prevented in rabbits receiving an intracisternal administration of either PAF antagonist CV6209 or BN52021 or anti-PAF IgG (p < 0.01 at a total dose of 20 micrograms and p < 0.05 at a total dose of 200 microgr...Continue Reading

References

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Citations

Feb 1, 1996·Biulleten' eksperimental'noĭ biologii i meditsiny·T P StorozhevykhO E Fadiukova
Jun 1, 1996·General Pharmacology·L H Thomas, J A Warner
Aug 10, 2002·Progress in Neurobiology·Karyn M MaclennanPaul F Smith
Dec 1, 1996·Progress in Neurobiology·K M MaclennanC L Darlington
Nov 22, 2011·World Neurosurgery·Robert G WhitmoreSherman C Stein
Nov 9, 2014·Translational Stroke Research·Yuichiro KikkawaTomio Sasaki
Jun 26, 2003·Neurosurgery·Aaron S DumontKevin S Lee
Sep 10, 2003·Journal of Cardiovascular Pharmacology·M Akif BayarHüseyin Ustün
Jun 19, 1998·Neurosurgery·R L MacdonaldP K Andrus
Dec 7, 2019·Cellular and Molecular Neurobiology·Kevin Min Wei KheySherif Hanafy Mahmoud

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Methods Mentioned

BETA
light microscopy

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