Platelet-activating factor (PAF) is a phospholipid mediator of anaphylaxis, released from basophils of several mammalian species, that aggregates platelets and releases their vasoactive amines. The ionophore A23 187 induced the release of PAF from rat and mouse peritoneal cells, a mixed cell population that was fractionated using 5--15% Ficoll gradients and adherence to plastic petri dishes. PAF was associated with large, acid phosphatase-containing, adherent mononuclear cells. Mastocytes did not release PAF but released histamine by the action of ionophore or 48/80; they could not be held responsible for inactivation of PAF or inhibition of the PAF-induced platelet aggregation. These data indicate that, besides blood basophils, peritoneal macrophages are a likely source for PAF, a result that adds a new important function to the macrophage:aggregation of platelets and liberation of their inflammatory and vasoactive substances.
Release of eosinophil chemotactic factor from human polymorphonuclear neutrophils by calcium ionophore A23187 and phagocytosis
Acute immune complex disease in rabbits. The role of complement and of a leukocyte-dependent release of vasoactive amines from platelets
Leukocyte-dependent histamine release from rabbit platelets. The role of IgE, basophils, and a platelet-activating factor
Studies on the time course of histamine release and morphological changes induced by histamine liberators in rat peritoneal mast cells
Platelet-activating factor, a new mediator of anaphylaxis and immune complex deposition from rabbit and human basophils
Reactions of isolated human asthmatic lung and bronchial tissue to a specific antigen; histamine release and muscular contraction
Platelets as target cells in rheumatoid arthritis and systemic lupus erythematosus: a platelet specific immunoglobulin inducing the release reaction
Gastrointestinal damage induced by platelet-activating factor. Inhibition by the corticoid, dexamethasone
The effects of antiallergic and bronchodilator drugs on platelet-activating factor (PAF-acether) induced bronchospasm and platelet aggregation
Is platelet-activating factor (PAF-acether) synthesis by murine peritoneal cells (PC) a two-step process?
Synthesis and biological activity of some structural analogs of platelet-activating factor (PAF-acether)
Platelet-activating factor acether (PAF-acether) involvement in acute inflammatory and pain processes
Mass spectrometric evidence for the presence of platelet-activating factor (1-0-alkyl-2-acetyl-sn-glycero-3-phosphocholine) in human amniotic fluid during labor
Ether lipid content and fatty acid distribution in rabbit polymorphonuclear neutrophil phospholipids
Intracellular Ca2+ concentration and H2O2 production in mouse peritoneal macrophages are stimulated by platelet activating factor
Effect of platelet activating factor on leukocytes. II. Enhancement of eosinophil chemotactic factor and beta-glucuronidase release
1-O-alkyl-2-O-acetyl-sn-glycero-3-phosphocholines: influence on aggregation and [3H]serotonin release of human thrombocytes
Phosphono-platelet activating factor I. Synthesis of 1-O-hexadecyl-2-O-acetyl-glyceryl-3-(2-trimethyl ammonium-methyl) phosphonate and its platelet activating potency
Synthesis and characterization of a radioiodinated, photoreactive and physiologically active analogue of platelet activating factor
Platelet-activating factor induces a platelet-dependent bronchoconstriction unrelated to the formation of prostaglandin derivatives
Mechanism(s) of the hypotensive effect of synthetic 1-O-octadecyl-2-O-acetyl-glycero-3-phosphorylcholine
Characteristics of the binding of platelet-activating factor to platelets of different animal species
Electrophysiological effects of platelet-activating factor (PAF-acether) in guinea-pig papillary muscles
Interactions between local inflammatory and systemic haematological effects of PAF-acether in the rat
Mechanisms of desensitization of vasodilatation induced by platelet-activating factor in hypertensive rats
Effect of platelet activating factor (PAF) on blood flow distribution in the spontaneously hypertensive rat
Platelet-activating factor stimulates production of prostaglandin E2 in murine osteoblast-like cell line MC3T3-E1
Thrombin-induced formation of a polar lipid material within platelets that possesses platelet-activating activity
Differential effects of prostacyclin and prostaglandin E1 on bronchoconstriction and thrombocytopenia during collagen and arachidonate infusions and anaphylactic shock in the guinea-pig
Inhibitory effect of prostacyclin (PGI2) on neutropenia induced by intravenous injection of platelet-activating-factor (PAF) in the rabbit
Picomole doses of platelet-activating factor predispose the gastric mucosa to damage by topical irritants
Effect of platelet-activating factor (PAF-acether) and its specific receptor antagonist, BN 52021, on interleukin 1 (IL1) release and synthesis by rat spleen adherent monocytes
Anaphylaxis is a serious allergic reaction that is rapid in onset and may cause death.
Basophils are myeloid cells with a high affinity IgE receptor and is involved in inflammatory responses during allergy. Discover the latest research on Basophils here.
Blood Clotting Disorders
Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.