Platelet-activating factor and macrophages. I. Evidence for the release from rat and mouse peritoneal macrophages and not from mastocytes

European Journal of Immunology
J M Mencia-Huerta, J Benveniste


Platelet-activating factor (PAF) is a phospholipid mediator of anaphylaxis, released from basophils of several mammalian species, that aggregates platelets and releases their vasoactive amines. The ionophore A23 187 induced the release of PAF from rat and mouse peritoneal cells, a mixed cell population that was fractionated using 5--15% Ficoll gradients and adherence to plastic petri dishes. PAF was associated with large, acid phosphatase-containing, adherent mononuclear cells. Mastocytes did not release PAF but released histamine by the action of ionophore or 48/80; they could not be held responsible for inactivation of PAF or inhibition of the PAF-induced platelet aggregation. These data indicate that, besides blood basophils, peritoneal macrophages are a likely source for PAF, a result that adds a new important function to the macrophage:aggregation of platelets and liberation of their inflammatory and vasoactive substances.


Jan 1, 1975·International Archives of Allergy and Applied Immunology·D C MorrisonP M Henson
Oct 1, 1968·The Journal of Experimental Medicine·N S Ranadive, C G Cochrane
Aug 1, 1954·The Journal of Experimental Medicine·D W FAWCETT
Jan 1, 1965·The Journal of Experimental Medicine·Z A COHN, B BENSON
Apr 16, 1960·Nature·I MOTA, W da SILVA


Jan 1, 1988·Veterinary Research Communications·J DawsonA D Sedgwick
Feb 1, 1988·Digestive Diseases and Sciences·J L Wallace, B J Whittle
Jul 15, 1984·Experientia·G CamussiG Emanuelli
Dec 1, 1982·Agents and Actions·E Jouvin-MarcheJ Benveniste
Feb 1, 1984·Agents and Actions·J A DenburgJ Bienenstock
Dec 1, 1981·Agents and Actions·J Benveniste
Dec 1, 1980·Agents and Actions·B B VargaftigJ Benveniste
Dec 1, 1991·Lipids·E Ninio, F Joly
May 7, 1982·European Journal of Pharmacology·A PrancanB B Vargaftig
Jan 21, 1983·European Journal of Pharmacology·P BessinJ Benveniste
Dec 9, 1983·European Journal of Pharmacology·J Björk, G Smedegård
Oct 15, 1984·European Journal of Pharmacology·P IñarreaM S Crespo
Apr 29, 1987·European Journal of Pharmacology·M A MartinsB B Vargaftig
Mar 31, 1987·European Journal of Pharmacology·E DavenasJ Benveniste
Apr 27, 1988·European Journal of Pharmacology·M A MartinsB B Vargaftig
Aug 22, 1994·European Journal of Pharmacology·G EmanuelliG Camussi
Aug 1, 1986·Pharmacological Research Communications·I Haye-LegrandJ Benveniste
Jan 1, 1985·Comparative Immunology, Microbiology and Infectious Diseases·R Roubin, J Benveniste

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