Platelet activating factor and systemic anaphylaxis in Nippostrongylus brasiliensis-sensitized rats: differential effects of PAF antagonists

British Journal of Pharmacology
R MathisonA D Befus

Abstract

1. The effects of two platelet-activating factor (PAF) antagonists, WEB 2086 and BN 52021, in reducing the changes in extravasation (Evans blue technique) and blood flow (radiolabelled microsphere method) to various organs and tissues following anaphylactic shock in the Nippostrongylus brasiliensis-sensitized rat were investigated. 2. Both antagonists attenuated anaphylaxis-induced increases in plasma protein leak in the trachea, stomach and small intestine, although they did not block extravasation in the colon and kidneys. 3. Anaphylaxis-induced decreases in blood flow to the adrenals were effectively antagonized by WEB 2086, although this antagonist did not reverse blood flow decreases to any other tissues. BN 52021, on the other hand, did not alter anaphylaxis-induced decreases in blood flow to the adrenals, but effectively prevented dramatic decreases in blood flow to the large and small bowel and spleen. 4. Anaphylactic shock produced marked reduction in blood pressure that was partly reversed by WEB 2086, whereas BN 52021 effectively blocked the decreases in cardiac output. 5. Thus, PAF is responsible for some of the haemodynamic and extravasation of protein changes associated with systemic anaphylaxis in the rat, althou...Continue Reading

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Citations

Dec 25, 2010·The Journal of Physiological Sciences : JPS·Chiaki KamikadoYasutaka Kurata
Sep 18, 1998·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·M NishidaN Arizono
Apr 26, 2001·The American Journal of Chinese Medicine·L Ho-subR Do-Gon
Mar 17, 2012·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Wei ZhangHideaki Tsuchida
Nov 23, 2019·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Charles TacquardPaul M Mertes

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Anaphylaxis

Anaphylaxis is a serious allergic reaction that is rapid in onset and may cause death.