Platelet-activating factor in normal rat uterus

Biochemical and Biophysical Research Communications
K YasudaK Saito

Abstract

Platelet-activating factor (PAF) was found in normal rat uterus and identified as 1-0-hexadecyl/octadecenyl-2-acetyl-sn-glycero-3-phosphocholine. PAF was purified by several successive chromatographic procedures. It showed platelet aggregating activity, which was inhibited by CV 3988, and had no effect on platelets desensitized with 1-0-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine. The tert-butyldimethyl-silylderivative of 1-0-alkyl-2-acetyl-sn-glycerol, which was obtained by hydrolysis of uterine PAF with phospholipase C, was analyzed by gas chromatography-mass spectrometry. One rat uterus contained approximately 21.3 ng of 1-0-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine. This is the first report of the occurrence of a significant amount of PAF in a normal animal tissue.

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Citations

Jul 21, 1998·Molecular Reproduction and Development·S Soubeyrand, P Manjunath
Jul 1, 1992·Molecular Reproduction and Development·M A JonesM J Harper
Sep 11, 1991·Biochimica Et Biophysica Acta·R NakayamaK Saito
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Jan 1, 1989·Archives of Oral Biology·K NoguchiS Murota

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