Platelet-activating factor mediates pulmonary macromolecular leak following intestinal ischemia-reperfusion

The Journal of Surgical Research
M B CarterR N Garrison

Abstract

Platelet-activating factor (PAF) causes hypotension, cardiac dysfunction, increased vascular permeability, intestinal necrosis, and pulmonary microvascular injury when administered experimentally. Receptor antagonism attenuates or abolishes many of these effects in animal models of bacteremia, endotoxemia, and intestinal ischemia/reperfusion (I/R). The purpose of this study was to further examine the role of PAF in intestinal I/R-induced pulmonary injury using the PAF receptor antagonist WEB 2086. Sprague-Dawley rats were anesthetized and cannulated for measurement of mean arterial pressure, heart rate, and cardiac output. Laparotomy and thoracotomy were performed and the superior mesenteric artery was occluded for 45 min and reperfused for 120 min. Sham animals were treated similarly but without I/R. In the treatment groups, iv WEB 2086 (20 mg/kg/l cc NS) was administered as a bolus 15 min prior to reperfusion. Hemodynamic and videomicroscopic data were obtained before and during ischemia, and after reperfusion at 30-min intervals. Alveolar leak index was calculated offline via computer analysis of videomicroscopic images. Intestinal I/R caused pulmonary macromolecular leakage and hemodynamic instability. Treatment with WEB 20...Continue Reading

Citations

Nov 11, 1999·American Journal of Respiratory and Critical Care Medicine·S FalkS Uhlig
Sep 3, 2002·American Journal of Respiratory and Critical Care Medicine·Rolf GöggelStefan Uhlig
Apr 5, 2012·Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine·Shinil K ShahCharles S Cox
Dec 16, 1998·The Japanese Journal of Physiology·Y TeramotoA Takada
Nov 19, 2015·Microbiology and Immunology·Eszter TubolyHidechika Okada
Jan 5, 2005·Free Radical Biology & Medicine·Koji ItoSaburo Horikawa
Jan 25, 2000·The Journal of Surgical Research·L C ClavijoR N Garrison
Apr 2, 2002·The Journal of Surgical Research·Thiruma V ArumugamStephen M Taylor
Jul 17, 2015·Journal of Intensive Care Medicine·Cornelia Griggs, Kathryn Butler
May 5, 2007·Microsurgery·Aki EnomotoEiji Kobayashi
Jan 6, 2004·Nature Medicine·Rolf GöggelStefan Uhlig
Jan 3, 2001·Journal of Applied Physiology·L C ClavijoR N Garrison
Oct 12, 1999·The American Journal of Physiology·S G Greenberg, K E Clark
Oct 25, 2003·Journal of Pediatric Surgery·M Cagri SavasNamik Delibas

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