PMID: 7538076Apr 15, 1995Paper

Platelet-activating factor produced by endothelial cells. A molecule with autocrine and paracrine properties

European Journal of Biochemistry
F Bussolino, G Camussi

Abstract

Endothelial cells (EC) participate in microenvironment homeostasis by regulating the trafficking of cells and molecules from the bloodstream to the tissues. The 'area codes' used to control the trafficking are adhesion molecules, receptors which pick up external signals, and mediators of cell-to-cell communication. Platelet-activating factor (PAF) is a mediator that belongs to this class of 'area-code' molecules. PAF is an acetylated derivative of phosphatidylcholine which is produced by EC and may act in an autocrine manner. Several stimuli may induce the synthesis of PAF by EC with different time courses. Thrombin, elastase and tumor necrosis factor (TNF) are prototypic molecules inducing very-early, early and delayed PAF synthesis, respectively. These stimuli activate the 'remodelling pathway' which requires the activation of phospholipase A2 and acetyl CoA:1-alkyl-2-lyso-sn-glycero-3-phosphate acetyltransferase. The effects of very-early and early stimuli are mediated by a direct stimulation of this pathway, whereas the action of TNF is mediated by the new synthesis of a serine protease. Stimulated EC produce PAF molecules with both an ether and an ester bond at the sn-1 position, but the former is predominant. The PAF prod...Continue Reading

References

Aug 13, 1991·Biochimica Et Biophysica Acta·K L ClayG S Worthen
Jul 1, 1994·The Journal of Experimental Medicine·G MontrucchioG Camussi

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Citations

Mar 29, 2000·Journal of Cellular Physiology·M BoccellinoG Camussi
Sep 4, 2012·Archivum Immunologiae Et Therapiae Experimentalis·Hsuan-Shun Huang, Hsin-Hou Chang
Nov 13, 2001·British Journal of Pharmacology·P N BernatchezM G Sirois
Apr 12, 2000·European Journal of Biochemistry·C DangelmaierS P Kunapuli
Nov 8, 2001·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·A J ArchambaultP S Haddad
Feb 13, 2004·The Journal of Trauma·Gregory P VictorinoBrian Curran
Apr 22, 2003·Infection and Immunity·Murray W StinsonSarmishtha Kumar
Dec 5, 2009·American Journal of Physiology. Gastrointestinal and Liver Physiology·Jie MaWeibiao Cao
Dec 25, 2010·Journal of Applied Physiology·Elizabeth L CuretonGregory P Victorino
Feb 3, 2006·The Journal of Pharmacy and Pharmacology·Chiara DianzaniRoberto Fantozzi
Jul 3, 2013·Molecular Nutrition & Food Research·Michel LagardeMichel Guichardant
Mar 28, 2008·Reproduction in Domestic Animals = Zuchthygiene·U Tiemann

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