Platelet-activating factor significantly enhances intrauterine insemination pregnancy rates in non-male factor infertility

Fertility and Sterility
W E RoudebushJoe B Massey

Abstract

To determine the efficacy of treating semen specimens with platelet-activating factor (PAF) before IUI. Prospective randomized double-blinded study of PAF treatment of sperm for patients with a history of infertility undergoing IUI. Private infertility center. Patients had ovulation induction therapy with clomiphene citrate (CC) or gonadotropin, two IUIs per month with PAF treatment. Clinical pregnancy rates. There was a significant difference in IUI pregnancy rates per cycle between control (10/56; 17.9%) and PAF (14/47; 29.8%) treatment groups in the normal male study arm. There was a significant difference in cumulative IUI pregnancy rates between control (10/35; 28.6%) and PAF (14/26; 53.9%) patient groups in the normal male study arm. There was no significant difference in IUI pregnancy rates per cycle between control (12/124; 9.7%) and PAF (14/119; 11.8%) treatment groups in the male factor study arm. There was no significant difference in cumulative IUI pregnancy rates between control (12/46; 26.1%) and PAF (14/38; 36.8%) patient groups in the male factor study arm. There was a significant difference in overall cumulative IUI pregnancy rates between control (21/81; 25.9%) and PAF (27/64; 42.2%) patient groups. The inclus...Continue Reading

References

Apr 1, 1993·American Journal of Obstetrics and Gynecology·B S Minhas
Jan 1, 1993·Journal of Assisted Reproduction and Genetics·W E RoudebushB S Minhas
May 7, 1999·Fertility and Sterility·J C ReinhardtW E Roudebush
Aug 6, 2000·Fertility and Sterility·W E Roudebush, E T Purnell
May 12, 2001·American Journal of Obstetrics and Gynecology·M D Wild, W E Roudebush
May 15, 2001·The Journal of Biological Chemistry·C WuT Shimuzu
Nov 29, 2002·Human Reproduction·L GarceauL L Davidson

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Citations

Nov 15, 2007·Reproductive Sciences·Scott E EdwardsCarmen J Williams
Feb 28, 2020·ELife·Luke L McGoldrick, Jean-Ju Chung
Jan 26, 2005·Journal of Medical Primatology·William E RoudebushHilton I Kort
Feb 15, 2007·Reproductive Biomedicine Online·Atef AliPierre Miron

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