PMID: 7539698Feb 1, 1995Paper

Platelet-activating factor: the effector of protein-rich plasma extravasation and nitric oxide synthase induction in rat immune complex peritonitis

British Journal of Pharmacology
A A SteilL Bosca

Abstract

1. The involvement of platelet-activating factor (PAF) in immune complex-induced/polymorphonuclear-mediated tissue injury was studied by use of a reverse passive Arthus (RPA) model in the peritoneal cavity of rats. 2. Extravasation of protein-rich plasma, accumulation of polymorphonuclear leukocytes (PMN), and the production of nitric oxide (NO) by resident peritoneal mononuclear phagocytes were assayed. 3. Treatment of rats with either UR-12460 or BB-823, two compounds which possess different chemical structures, but elicit the same antagonistic effect on the PAF receptor, abrogated protein-rich plasma extravasation. In contrast, they did not show any effect on the accumulation of PMN. 4. Inhibition of NO production with both NG-mono methyl-L-arginine and NG-nitro-L-arginine failed to prevent protein-rich plasma extravasation. 5. The production of NO by peritoneal adherent cells following RPA was measured in cells maintained for 2 to 28 h in culture, and it was significantly increased in cells removed as early as 15 min after RPA induction, as compared to controls. 6. Addition of 10 nM PAF to the culture medium reduced the generation of NO by peritoneal cells from RPA rats, whereas this mediator enhanced NO production in cells...Continue Reading

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Citations

Dec 16, 1998·European Journal of Pharmacology·A A SteilS Jancar
Sep 24, 2004·Trends in Pharmacological Sciences·Nieves FernándezMariano Sánchez Crespo
Jan 23, 2015·Journal of Diabetes Research·Clifford T MaurielloKenji M Cunnion
Jan 15, 1998·Gastroenterology·J C HallC Platell
Oct 9, 2003·The Journal of Biological Chemistry·Nieves FernándezMariano Sánchez Crespo

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