Platelet activation and interactions with the microvasculature

Journal of Cardiovascular Pharmacology
S C Body

Abstract

Platelet adherence to structurally or functionally damaged endothelium and its subsequent activation are multifaceted events. Regulation of the rate and extent of platelet adhesion is under local control by the platelets and endothelium. Even in the absence of platelet adhesion to endothelium or subendothelium, there is a complex hemostatic balance of coagulation and anticoagulation. This is mediated by the manufacture, release, and inactivation of various procoagulant and anticoagulant compounds, predominantly by the platelets and endothelium. The relationship between the two in maintaining the homeostasis of coagulation and other processes is complex. This review focuses on the structure, function, and interaction of endothelium, subendothelium, and platelets and on their vasoactive and pro-/anticoagulant functions.

References

Sep 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·J S StamlerJ Loscalzo
Jul 1, 1992·The Journal of Cell Biology·K L MooreR P McEver
Jul 1, 1992·Acta Physiologica Scandinavica·S Moncada
Aug 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·J S StamlerJ Loscalzo
Jun 1, 1992·Blood Reviews·R W Faint
Jun 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·P KubesD N Granger
Jul 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·M W RadomskiS Moncada
Jul 1, 1990·Cellular Immunology·M KingA D Schreiber
Jul 1, 1990·British Journal of Haematology·P G de Groot, J J Sixma
Jun 1, 1990·The American Journal of Physiology·P Ferrer-LopezM Chignard
Mar 1, 1988·British Journal of Pharmacology·M Feletou, P M Vanhoutte
Nov 13, 1987·Biochemical and Biophysical Research Communications·M W RadomskiS Moncada
Dec 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·L J IgnarroG Chaudhuri
Jul 1, 1985·Journal of Clinical Pathology·N A BoothB Bennett
Aug 27, 1966·British Medical Journal
Aug 27, 1966·British Medical Journal· Florey
Sep 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·S E Rittenhouse
Nov 1, 1980·The Journal of Clinical Investigation·A J MarcusM J Broekman
Jan 1, 1993·Journal of Cardiovascular Pharmacology·M E DockrellD J Webb
May 25, 1994·Biochimica Et Biophysica Acta·A Muruganandam, B Mutus
Apr 18, 1994·Annals of the New York Academy of Sciences·R P McEver
Sep 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·L J IgnarroR E Byrns
Apr 18, 1994·Annals of the New York Academy of Sciences·W A BuechlerR Gerzer
Aug 1, 1993·Circulation·S Ballin, C Louis
Jun 1, 1993·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·D I SimonJ Loscalzo

❮ Previous
Next ❯

Citations

Jan 8, 2004·Microvascular Research·Andrew M RobertsDavid Lominadze
Apr 20, 1999·The Journal of Experimental Medicine·S MassbergF Hofmann
Jun 6, 2012·Thrombosis·Silvia Perez-PujolGines Escolar
May 25, 2007·Archives of Physiology and Biochemistry·Alexander V OvechkinAndrew M Roberts
Dec 15, 2015·Acta Biomaterialia·Aditi SainiLarry D Unsworth
Aug 23, 2012·Xenotransplantation·Hayato IwaseMohamed B Ezzelarab
Jan 30, 2013·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Alejandro Pelaez-VargasFernando J Monteiro
Dec 31, 1997·Journal of Cardiothoracic and Vascular Anesthesia·S E McNultyH Schieren
Oct 1, 1996·The Annals of Thoracic Surgery·F W SellkeE D Verrier
Aug 24, 2006·Journal of Vascular Research·Rainer KiefmannAlwin Eduard Goetz
Jul 13, 2000·Journal of Cardiovascular Pharmacology·F ReisF Teixeira
Aug 2, 2012·Pharmaceutical Biology·Sumitra ChandaVinay Shukla
Jun 22, 1999·Head & Neck·R M Esclamado, W R Carroll
Oct 22, 2002·American Journal of Physiology. Gastrointestinal and Liver Physiology·Janice RussellD Neil Granger

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.