Platelet activation in carotid sinuses triggers reflex sympathoinhibition and hypotension

Hypertension
H Z MaoM W Chapleau

Abstract

The carotid sinuses, one of the major sites of baroreceptor innervation, are also a common site of atherosclerotic lesions and platelet aggregation. The goal of the present study was to determine whether platelet activation in carotid sinuses causes reflex-mediated changes in renal sympathetic nerve activity and arterial pressure. Rabbit platelets were isolated, resuspended in Krebs' buffer, and activated by thrombin. Injection of activated platelets (3 x 10(8) platelets/mL) into the vascularly isolated carotid sinuses of anesthetized rabbits essentially eliminated sympathetic nerve activity and acutely decreased mean arterial pressure from 126 +/- 5 to 53 +/- 4 mm Hg (n=16; P < .05). Sympathetic activity and arterial pressure returned to control levels over a period of minutes despite sustained exposure to activated platelets. Injection of U-46619, a thromboxane analogue and vasoconstrictor, into carotid sinuses did not alter sympathetic activity or arterial pressure. However, serotonin (5-hydroxytryptamine [5-HT]), which is known to be released from activated platelets, and the 5-HT3 receptor agonist phenylbiguanide mimicked the effect of platelets. Furthermore, the platelet-induced reflex inhibition of sympathetic activity a...Continue Reading

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Citations

Mar 11, 2004·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Robert M Martinek
Apr 5, 2014·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Christian E OberkoflerPierre-Alain Clavien
Mar 11, 2000·Pharmacotherapy·C M White, J P Tsikouris
Jul 19, 2001·Annals of the New York Academy of Sciences·M W ChapleauF M Abboud
Feb 17, 2001·American Journal of Physiology. Heart and Circulatory Physiology·D O ArnarJ B Martins

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