Abstract
The carotid sinuses, one of the major sites of baroreceptor innervation, are also a common site of atherosclerotic lesions and platelet aggregation. The goal of the present study was to determine whether platelet activation in carotid sinuses causes reflex-mediated changes in renal sympathetic nerve activity and arterial pressure. Rabbit platelets were isolated, resuspended in Krebs' buffer, and activated by thrombin. Injection of activated platelets (3 x 10(8) platelets/mL) into the vascularly isolated carotid sinuses of anesthetized rabbits essentially eliminated sympathetic nerve activity and acutely decreased mean arterial pressure from 126 +/- 5 to 53 +/- 4 mm Hg (n=16; P < .05). Sympathetic activity and arterial pressure returned to control levels over a period of minutes despite sustained exposure to activated platelets. Injection of U-46619, a thromboxane analogue and vasoconstrictor, into carotid sinuses did not alter sympathetic activity or arterial pressure. However, serotonin (5-hydroxytryptamine [5-HT]), which is known to be released from activated platelets, and the 5-HT3 receptor agonist phenylbiguanide mimicked the effect of platelets. Furthermore, the platelet-induced reflex inhibition of sympathetic activity a...Continue Reading
References
Jan 1, 1976·Physiological Reviews·H R Kirchheim
Oct 1, 1978·The Journal of Clinical Investigation·R L CzervionkeG L Fry
Sep 1, 1975·British Journal of Pharmacology·K Nishi
Jul 1, 1992·British Journal of Pharmacology·M YoshiokaH Saito
Jun 1, 1992·FEBS Letters·B AttaliJ Barhanin
Aug 1, 1991·The Biochemical Journal·M P KavanaughR A North
Oct 18, 1991·Science·A V MaricqD Julius
Sep 1, 1990·Clinical and Experimental Pharmacology & Physiology·R G EvansJ Michalicek
Dec 15, 1989·Thrombosis Research·Y IsakaT Kamada
Aug 1, 1989·Journal of Applied Physiology·E P ChristianD Weinreich
Jan 1, 1987·British Journal of Pharmacology·S J Ireland, M B Tyers
Feb 1, 1972·British Journal of Haematology·J F MustardM A Packham
May 1, 1973·The Journal of Pathology·D HeathM Winson
Nov 1, 1982·Archives of Surgery·R J LusbyE J Wylie
May 1, 1984·Naunyn-Schmiedeberg's Archives of Pharmacology·J R Fozard
Sep 1, 1984·British Journal of Pharmacology·G C Kirby, D S McQueen
Aug 1, 1995·The American Journal of Physiology·Z LiM W Chapleau
Oct 1, 1993·British Journal of Pharmacology·J A PetersJ J Lambert
Jan 20, 1995·Journal of the Autonomic Nervous System·Z Li, M W Chapleau
Jan 1, 1995·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·L M Amzel, B J Gaffney
Jan 1, 1994·Pharmacology & Therapeutics·G R Martin
Mar 28, 1994·Neuroscience Letters·M RingkampP W Reeh
Aug 29, 1957·The Journal of Physiology·W W DOUGLAS, J M RITCHIE
Nov 23, 1951·Science·C HEYMANS, A L DELAUNOIS
Jan 1, 1952·Acta Physiologica Scandinavica·S LANDGRENY ZOTTERMAN
Citations
Mar 11, 2004·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Robert M Martinek
Nov 22, 2011·International Journal of Obstetric Anesthesia·T SahooA Hazra
Apr 5, 2014·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Christian E OberkoflerPierre-Alain Clavien
Aug 5, 2008·Regional Anesthesia and Pain Medicine·Radoslaw OwczukMaria Wujtewicz
Mar 11, 2000·Pharmacotherapy·C M White, J P Tsikouris
Feb 19, 2000·Hypertension·K WilfertH M Stauss
Jul 19, 2001·Annals of the New York Academy of Sciences·M W ChapleauF M Abboud
Feb 17, 2001·American Journal of Physiology. Heart and Circulatory Physiology·D O ArnarJ B Martins
Jan 26, 2021·Curēus·Abhishek ChatterjeeRajiv Shukla