Platelet Additive Solutions: A Review of the Latest Developments and Their Clinical Implications

Transfusion Medicine and Hemotherapy : Offizielles Organ Der Deutschen Gesellschaft Fur̈ Transfusionsmedizin Und Immunham̈atologie
P F van der Meer, Dirk de Korte

Abstract

Summary Platelet additive solutions (PASs) have undergone many reformulations in order to further improve platelet storage. Studies of platelets stored in PAS-F (containing acetate, magnesium and potassium as key constituents) showed that platelets may be stored for 13 days with recovery and survival outcomes that are equal or even superior to 7-day stored platelets in plasma. Clinically, patients transfused with platelets in PAS have fewer allergic reactions, while for febrile reactions data are conflicting. Transfusion-related acute lung injury (TRALI) occurs less frequently if PAS is used for buffy coat-derived platelets, but for apheresis platelets there is no difference. For PAS-B and PAS-C, corrected count increments (CCIs) are lower than for platelets stored in plasma, but for PAS-E (like PAS-F also with acetate, magnesium and potassium but with additional phosphate), though limited data is available in the literature, the CCIs seem to be comparable to those observed for platelets in plasma. With platelets in PAS, there is an accumulated dilution effect of anticoagulant and PAS as well as a loss of number and function (due to storage and/or pathogen inactivation treatment) of platelets, of which it is not clear how this ...Continue Reading

Citations

Sep 16, 2020·Hämostaseologie·Michel Prudent
Jan 8, 2021·Anesthesiology·Aaron Stansbury HessJohn Rider Hess
Jun 17, 2020·Transfusion clinique et biologique : journal de la Société française de transfusion sanguine·M R DeyhimF Khoshnaghsh
Jan 29, 2020·Transfusion Medicine Reviews·Sarah M GreenLacey Johnson
Mar 13, 2021·Hämostaseologie·Fabrice CognassePeter Larsen
Dec 9, 2020·Pediatrics International : Official Journal of the Japan Pediatric Society·Ryu Yanagisawa
Apr 7, 2021·American Journal of Clinical Pathology·Tayler A van den AkkerMark T Friedman
Jun 3, 2021·Journal of Clinical Medicine·Annina CapraruBehrouz Mansouri Taleghani
Aug 17, 2021·Platelets·Peter Smethurst, Rebecca Cardigan
Nov 9, 2019·Transfusion Medicine and Hemotherapy : Offizielles Organ Der Deutschen Gesellschaft Fur̈ Transfusionsmedizin Und Immunham̈atologie·Sami ValkonenSaara Laitinen

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