Platelet adhesion: a game of catch and release.

The Journal of Clinical Investigation
Robert K Andrews, M C Berndt

Abstract

The interaction of circulating platelets with the vessel wall involves a process of cell catch and release, regulating cell rolling, skipping, or firm adhesion and leading to thrombus formation in flowing blood. In this regard, the interaction of platelet glycoprotein Ibalpha (GPIbalpha) with its adhesive ligand, vWF, is activated by shear force and critical for platelet adhesion to the vessel wall. In this issue of the JCI, Yago and colleagues show how gain-of-function mutations in the GPIbalpha-binding vWF A1 domain disrupt intramolecular interactions within WT vWF A1 that regulate binding to GPIbalpha and flow-enhanced platelet rolling and adhesion (see the related article beginning on page 3195). Together, these studies reveal molecular mechanisms regulating GPIbalpha-vWF bond formation and platelet adhesion under shear stress.

References

Jan 1, 1997·The International Journal of Biochemistry & Cell Biology·R K AndrewsM C Berndt
Jun 23, 2000·Nature·K AutumnR J Full
May 9, 2003·Nature·Bryan T MarshallCheng Zhu
May 22, 2003·The International Journal of Biochemistry & Cell Biology·R K AndrewsM C Berndt
Sep 27, 2006·The Journal of Cell Biology·Jizhong LouRodger P McEver
Feb 22, 2007·Blood·Shaun P Jackson
Mar 28, 2008·Biochemical Society Transactions·Deborah Leckband

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Citations

Oct 16, 2012·American Journal of Physiology. Heart and Circulatory Physiology·Alkystis PhinikaridouRené M Botnar
Apr 17, 2012·American Journal of Physiology. Lung Cellular and Molecular Physiology·Memet T EminSunita Bhattacharya
Jul 4, 2012·International Journal of Molecular Sciences·Weilin ZhangKesheng Dai
Oct 2, 2012·Blood Reviews·Elizabeth E Gardiner, Robert K Andrews
May 25, 2012·Journal of Molecular Graphics & Modelling·Jian LiYan Sun
Sep 24, 2011·Advances in Medical Sciences·A WasilukS Redzko
Jun 26, 2010·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Reiner HajoschBurkhard Schlosshauer
Jul 23, 2015·Biophysical Journal·Michael T ZimmermannMatthew Auton
Sep 18, 2010·JACC. Cardiovascular Imaging·Owen J T McCartyJonathan R Lindner
Aug 11, 2016·Biophysical Journal·Shirin FeghhiNathan J Sniadecki
Apr 30, 2017·Biointerphases·Colin D Eichinger, Vladimir Hlady

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Methods Mentioned

BETA
atomic force microscopy
AFM

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