Platelet adhesion on to polyamide microcapsules coated with lipid bilayer membrane.

Biomaterials
K KonoY Imanishi

Abstract

Polyamide microcapsules with diameters of 3-4 microns were coated with lipid bilayer membrane and their interaction with canine platelets was investigated. Platelet adhesion on to the microcapsules was significantly suppressed by the lipid-coating. Coating with dimyristoylphosphatidylcholine (liquid-crystalline state) reduced platelet adhesion on to the microcapsules to a greater extent than that with dipalmitoylphosphatidylcholine (gel state) at 37 degrees C. The surface properties of the microcapsule in adsorption of plasma proteins were also changed by lipid coating. The amount of gamma-globulin and fibrinogen adsorbed on to the microcapsule was slightly decreased by lipid coating, while the amount of adsorbed albumin was increased. Platelet adhesion on to the lipid-coated microcapsules was suppressed most strongly in the presence of gamma-globulin. Apparently platelet adhesion on to the polyamide microcapsules is controlled by the nature of lipid membrane and gamma-globulin adsorbed on to the microcapsules.

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Citations

Jul 9, 1999·Journal of Biomedical Materials Research·Y IwasakiK Ishihara
Dec 1, 1992·Journal of Biomedical Materials Research·K IshiharaN Nakabayashi
Oct 1, 1993·Journal of Biomedical Materials Research·K IshiharaN Nakabayashi
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Jul 17, 2007·Langmuir : the ACS Journal of Surfaces and Colloids·D V AndreevaG B Sukhorukov
Jul 31, 2018·Langmuir : the ACS Journal of Surfaces and Colloids·Kazuhiko Ishihara

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